Progeria

Talbot, Ńathan B.; Butler, Allan M.; Pratt, Edward L.; MacLachlan, E. A.; Tannheimer, J.

doi:10.1001/archpedi.1945.02020170002001

Cited by 48 publications

(6 citation statements)

References 24 publications

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“…Makhous et al found only 2 of 32 subjects in the literature with values of 300 mg=dL or above and 5 above 275 mg=dL. Eight were above 270 mg=dL and, for the young ages, such values would normally be regarded as elevated but there was evidence of lability [32]. One girl considered to have high normal serum cholesterol at age 2 years 3 months was given a high polyunsaturated fat diet until she died at 10 years of age of myocardial infarction and congestive cardiac failure with no apparent e¡ect on atherogenesis [18].…”

Section: Discussionmentioning

confidence: 99%

Hutchinson-Gilford Progeria Syndrome: A Pathologic Study

Ackerman

Gilbert‐Barness

2002

Pediatric Pathology & Molecular Medicine

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Hutchinson-Gilford progeria syndrome is an extremely rare condition with features of premature and accelerated aging.The pattern of inheritance is unclear, although both autosomal recessive and autosomal dominant modes have been proposed. The children usually present in late infancy and early childhood with a characteristic phenotype of alopecia; short stature; abnormal skin, teeth, and nails; beaked nose; loss of subcutaneous fat; and failure to thrive.This condition has been reported on all inhabited continents and has been described in all major races. Laboratory ¢ndings note an increased urinary excretion of hyaluronic acid. Death results from cardiovascular abnormalities in the majority of cases and usually occurs in the second decade of life. There is no e¡ective treatment.We report the pathologic changes noted at autopsy on a 20-year-old woman with classic features of Hutchinson-Gilford progeria syndrome.

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Section: Discussionmentioning

confidence: 99%

Hutchinson-Gilford Progeria Syndrome: A Pathologic Study

Ackerman

Gilbert‐Barness

2002

Pediatric Pathology & Molecular Medicine

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“…No details are available concerning the last seven years of life of the remaining case (Variot and Pironneau, 1910;Variot, 1921). The earliest age at which any clinical manifestations of coronary sclerosis have been reported in a case of progeria is 7 years (Talbot, Butler, Pratt, MacLachlan and Tannheimer, 1945).…”

Section: Discussionmentioning

confidence: 99%

Progeria and Atherosclerosis

Keay¹,

Oliver²,

Boyd³

1955

Archives of Disease in Childhood

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“…In some cases the skin becomes dry, rough, and scaly. The nails and the mouth may become infected with moniliasis in idiopathic hypoparathyroidism (Thorpe and Handley, 1929;Sevringhaus, 1942;Sutphin et al, 1943;Talbot et al, 1943). Impetigo herpetiformis has also been described as an association with chronic tetany (Lachmann, 1941).…”

Section: Mode Of Presentationmentioning

confidence: 99%

“…Addison's disease has been associated with idiopathic hypoparathyroidism in three cases (Sutphin et al, 1943;Talbot et al, 1943;Leonard, 1946). In Leonard's case necropsy showed atrophy of the adrenal glands as well as absence of the parathyroids; in the case of Sutphin et al…”

Section: Mode Of Presentationmentioning

confidence: 99%