Progenitors of Interstitial Cells of Cajal in the Postnatal Murine Stomach

Lörincz, Andrea; Redelman, Doug; Horváth, Viktor J.; Bardsley, Michael R.; Chen, Hui; Ördög, Tamás

doi:10.1053/j.gastro.2008.01.036

Cited by 140 publications

(212 citation statements)

References 37 publications

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“…It has previously been proposed that CD34‐positive fibroblast‐like ICCs cells were progenitors of c‐kit‐positive ICCs in the intestine 43, 44. Our data point to the presence of CD34‐positive cells surrounding prostatic budding on the early prostate development, later CD34/c‐kit‐positive cells and c‐kit‐positive cells are verified in this region, while CD34‐positive cells form a network of telopodes in the interalveolar region.…”

Section: Discussionsupporting

confidence: 66%

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Sanches

Maldarine

Zani

et al. 2017

J Cellular Molecular Medi

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Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes in the myocardium. The existence of telocytes in the prostate has recently been reported, however, there is a lack of information regarding the function of these cells in prostate tissue, and information regarding the possible role of these cells in prostatic development. This study used immunofluorescence techniques in prostate tissue and prostatic telocytes in culture to determine the relationship between telocytes and prostate morphogenesis. Furthermore, immunofluorescent labelling of telocytes was performed on prostate tissue at different stages of early postnatal development. Initially, CD34‐positive cells are found at the periphery of the developing alveoli, later in the same region, c‐kit‐positive cells and cells positive for both factors are verified and CD34‐positive cells were predominantly observed in the interalveolar stroma and the region surrounding the periductal smooth muscle. Fluorescence assays also demonstrated that telocytes secrete TGF‐β1 and are ER‐Beta (ERβ) positive. The results suggest that telocytes play a changing role during development, initially supporting the differentiation of periductal and perialveolar smooth muscle, and later, producing dense networks that separate alveoli groups and form a barrier between the interalveolar region and periurethral smooth muscle. We conclude that telocytes play a relevant role in prostate tissue organisation during postnatal development.

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Section: Discussionsupporting

confidence: 66%

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Sanches

Maldarine

Zani

et al. 2017

J Cellular Molecular Medi

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“…In healthy, ICC numbers are dynamic (39) indicating that the integrity of the ICC networks has to be tightly controlled with processes that regulate both ICC loss and ICC replacement. ICC loss might be due to apoptosis (39) and trans/ de-differentiation (40,41) whereas ICC replacement includes cell repair, proliferation from adult ICC and ICC stem cell precursors proliferation (42). As reported above, the c-Kit signaling pathway is responsible for ICC development and maintenance of the phenotype.…”

Section: Icc and Nerve Contactsmentioning

confidence: 93%

“…Therefore, the possibility that local ICC precursors are present in the gut wall has taken hold. Studies in postnatal murine gastric muscle revealed rare cells that expressed very low level of c-Kit and normal level of CD44, CD34, Ano-1, and receptors for insulin and IGF-1 (42,43). In adult mouse colon, 14 days after BAC treatment, the damaged areas re-innervated and together with the nerve structures, cells with FLC features were detected.…”

Section: Icc and Nerve Contactsmentioning

confidence: 99%

Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?

Vannucchi

Traini

2016

Biomolecular Concepts

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Abstract:In the interstitium of the connective tissue several types of cells occur. The fibroblasts, responsible for matrix formation, the mast cells, involved in local response to inflammatory stimuli, resident macrophages, plasma cells, lymphocytes, granulocytes and monocytes, all engaged in immunity responses. Recently, another type of interstitial cell, found in all organs so far examined, has been added to the previous ones, the telocytes (TC). In the gut, in addition to the cells listed above, there are also the interstitial cells of Cajal (ICC), a peculiar type of cell exclusively detected in the alimentary tract with multiple functions including pace-maker activity. The possibility that TC and ICC could correspond to a unique cell type, where the former would represent an ICC variant outside the gut, was initially considered, however, further studies have clearly shown that ICC and TC are two distinct types of cells. In the gut, while the features and the roles of the ICC are established, part of the scientific community is still disputing these 'new' interstitial cells to which several names such as fibroblast-like cells (FLCs), interstitial Cajal-like cells or, most recently, PDGFRα + cells have been attributed. This review will detail the main features and roles of the TC and ICC with the aim to establish their relationships and hopefully define the identity of the TC in the gut.

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“…No other major cell type in the small intestine appears to express CD44 (Chen et al 2007). Lorincz et al (2008) found that mature ICC are Kit …”

mentioning

confidence: 99%

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Huang

Tong

et al. 2010

Tohoku J. Exp. Med.

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Progenitors of Interstitial Cells of Cajal in the Postnatal Murine Stomach

Cited by 140 publications

References 37 publications

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

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