Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue

Park, Jooman; Shin, Sunhye; Liu, Lifeng; Jahan, Iffat; Ong, Sang-Ging; Xu, Pingwen; Berry, Daniel C.; Jiang, Yuwei

doi:10.1016/j.devcel.2021.02.018

Cited by 33 publications

(36 citation statements)

References 67 publications

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“…Finally, we were somewhat surprised that we did not see a murine population that could be clearly delineated as thermogenic. Such cells have been noted by others in WAT, even at room temperature 36 . Notably, the distribution of beige adipocytes is not uniform in ING, but tends to be densest close to the inguinal lymph node (LN) 37 .…”

Section: Adipocytes Of Mice and Humans Show Critical Similarities And Differencessupporting

confidence: 60%

A single cell atlas of human and mouse white adipose tissue

Emont

Jacobs

Essene

et al. 2021

Preprint

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White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control, and host defense1. High fat feeding and other metabolic stressors cause dramatic changes in adipose morphology, physiology, and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia, and type 2 diabetes (T2D)2. Here, we provide detailed cellular atlases of human and murine subcutaneous and visceral white fat at single cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells (ASPCs), vascular, and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease, and we provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits, and cell types in the function of WAT across species, depots, and nutritional conditions.

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Section: Adipocytes Of Mice and Humans Show Critical Similarities And Differencessupporting

confidence: 60%

A single cell atlas of human and mouse white adipose tissue

Emont

Jacobs

Essene

et al. 2021

Preprint

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“…Beige adipocytes can be generated within WAT depots via three mechanisms: (1) the differentiation of progenitor cells into new beige adipocytes (i.e., de novo beige adipogenesis), (2) phenotypic conversion of mature white adipocytes into beige adipocytes through the activation (or reactivation) of the thermogenic program, and (3) the proliferation of mature beige adipocytes (Park et al, 2021;Shao et al, 2019;Wang et al, 2013). Activation of the thermogenic program in adipocytes involves upregulation of thermogenic genes such as Ucp1, mitochondrial biogenesis, and lipid-droplet remodeling from a unilocular to multilocular morphology (Kim et al, 2019).…”

Section: Thermogenic Adaptation In Adipose Tissuementioning

confidence: 99%

“…For example, in mice that have recently undergone cold exposure, reactivation of dormant beige cells predominates, whereas in cold naive animals de novo beige-adipocyte differentiation from progenitor cells is favored (Shao et al, 2019). Interestingly, a subset of UCP1+ cells, specifically in the central region of iWAT (near the lymph nodes) exhibit proliferative capacity and generate new beige adipocytes in response to b-adrenergic stimulation (Park et al, 2021).…”

Section: Adipose-tissue Whiteningmentioning

confidence: 99%

Adipose-tissue plasticity in health and disease

Sakers

Siqueira

Seale

et al. 2022

Cell

384

216

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“… 24 Therefore, promoting UCP1+ cell division enhances thermogenesis, and blocking UCP1+ cell division suppresses thermogenesis in vivo . 25 …”

Section: Adipose Tissue Biologymentioning

confidence: 99%

Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms

Shin

2022

Journal of Obesity & Metabolic Syndrome

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Long-chain fatty acids (LCFA) modulate metabolic, oxidative, and inflammatory responses, and the physiological effects of LCFA are determined by chain length and the degree of saturation. Adipose tissues comprise multiple cell types, and play a significant role in energy storage and expenditure. Fatty acid uptake and oxidation are the pathways through which fatty acids participate in the regulation of energy homeostasis, and their dysregulation can lead to the development of obesity and chronic obesity-related disorders, including type 2 diabetes, cardiovascular diseases, and certain types of cancer. Numerous studies have reported that many aspects of adipose tissue biology are influenced by the number and position of double bonds in LCFA, and these effects are mediated by various signaling pathways, including those regulating adipocyte differentiation (adipogenesis), thermogenesis, and inflammation in adipose tissue. This review aims to describe the underlying molecular mechanisms by which different types of LCFA influence adipose tissue metabolism, and to further clarify their relevance to metabolic dysregulation associated with obesity. A better understanding of the effects of LCFA on adipose tissue metabolism may lead to improved nutraceutical strategies to address obesity and obesity-associated diseases.

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Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue

Cited by 33 publications

References 67 publications

A single cell atlas of human and mouse white adipose tissue

A single cell atlas of human and mouse white adipose tissue

Adipose-tissue plasticity in health and disease

Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms

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