Progenitor-Enriched Adipose Tissue Transplantation as Rescue for Breast Implant Complications

Abstract

Breast enhancement with artificial implants is one of the most frequently performed cosmetic surgeries but is associated with various complications, such as capsular contracture, that lead to implant removal or replacement at a relatively high rate. For replacement, we used transplantation of progenitor-supplemented adipose tissue (cell-assisted lipotransfer; CAL) in 15 patients. The stromal vascular fraction containing adipose tissue progenitor cells obtained from liposuction aspirates was used to enrich for progenitor cells in the graft. Overall, clinical results were very satisfactory, and no major abnormalities were seen on magnetic resonance imaging or mammogram after 12 months. Postoperative atrophy of injected fat was minimal and did not change substantially after 2 months. Surviving fat volume at 12 months was 155 +/- 50 mL (Right; mean +/- SD) and 143 +/- 80 mL (Left) following lipoinjection from an initial mean of 264 mL. These preliminary results suggest that CAL is a suitable methodology for the replacement of breast implants.

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

“…More than 100,000 breast reconstructions after mastectomy, and over 200,000 maxillofacial surgeries were performed in 2015 alone and it is predicted that there will be more than 12,000 new cases of soft-tissue sarcomas in the USA in 2016 [9,67]. The current treatment for many of these conditions is autologous lipotransfer, a procedure involving collecting fat tissue from a patient, minimally manipulating the resultant lipoaspirate and relocating it to the site of reconstruction [68][69][70][71]. Although used widely, reports show that there is extensive variability of longterm lipotransfer graft survival, due to unpredictable degrees of resorption and tissue volume loss that can range from 20 to 90% [32,72,73].…”

Using Breast MRI to Evaluate Complications of Autologous Fat Grafting

“…In contrast to the aforementioned successful cases, these patients require life-long follow up for breast cancer screening because of the difficulty of cancer detection. These patients should also undergo long-term imaging analyses [6,7]. Autologous fat grafts are also believed to have the disadvantage of the unpredictability graft tissue survival because of fat necrosis and re-absorption [8].…”

Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics

“…This evolving field is taking over the recent medical era as it combines growth factors, biomaterials, and stem cells to repair failing organs relying on fast and efficient tissue growth [1,2]. Regenerative medicine is being applied in orthopedics.…”