Abstract:Global mRNA translation may differ dramatically between progenitor cells
and their differentiated progeny. One way cell type-specific translation
is established is through ribosome concentration. In addition to
addressing unique metabolic needs, changes in ribosome concentration may
influence cell fate. The mechanisms that determine ribosome abundance in
progenitors versus differentiated progeny are not fully understood. Here
we investigated this process by focusing on ribosomal RNA (rRNA)
synthesis in Drosoph… Show more
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