2003
DOI: 10.1159/000074191
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Progenitor Cells from Human Embryonic Retina – Proliferation and Preferential Differentiation into Ganglion Cells

Abstract: Progenitor cells of the retina give rise to 6 principle types of neurons and the Müller glia cells. In the human retina, differentiation starts at around the beginning of the third month of gestation with the appearance of first postmitotic ganglion cells. As histogenesis proceeds, the remaining types of neurones and the Müller glial cells are generated. The precise mechanisms by which multipotent retinal progenitor cells are guided to give rise to the different postmitotic cell types are largely unknown. Here… Show more

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Cited by 3 publications
(3 citation statements)
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“…Aggregate cultures have been generated from dissociated primary retinal tissues from both fetal and adult retina. [48][49][50] The ability to maintain and expand primitive undifferentiated human retinal progenitors in cultures will be valuable in the study of human retinal genes, and possibly could be used for treatment of degenerative retinal diseases.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Aggregate cultures have been generated from dissociated primary retinal tissues from both fetal and adult retina. [48][49][50] The ability to maintain and expand primitive undifferentiated human retinal progenitors in cultures will be valuable in the study of human retinal genes, and possibly could be used for treatment of degenerative retinal diseases.…”
Section: Discussionmentioning
confidence: 99%
“…These progenitors when grown attached to cytodex beads in the NASA-developed rotating culture vessel system and formed large 3D constructs. 50,51 We realized that until well-defined biocompatible substrates could be generated, we will be unable to test these transplants in an animal model.…”
Section: Discussionmentioning
confidence: 99%
“…The isolation and propagation of hNPCs were in accordance with the Ethical Principles for Medical Research involving Human Subjects of the Declaration of Helsinki and were approved by the local ethics committee and that of the University of Rostock. Isolation and propagation of cells were essentially as described for retinal precursors (Andressen et al. 2003).…”
Section: Methodsmentioning
confidence: 99%