Profound thrombocytopenia due to <i>Plasmodium vivax</i> malaria

Anstey, Nicholas M.; Currie, Bart J.; Dyer, Mary E.

doi:10.1111/j.1445-5994.1992.tb02801.x

Cited by 6 publications

(5 citation statements)

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“…[18] Recent studies have shown that thrombocytopenia is equally or even more common in P. vivax malaria contrary to the popular belief that it may be observed in P. falciparum malaria. [22232425262728] More recent data in India has shown how thrombocytopenia exhibited a heightened frequency and severity among patients with P. vivax infections. [29] Recent studies conducted from the Indian subcontinent have found significant thrombocytopenia in P. vivax malaria.…”

Section: Discussionmentioning

confidence: 99%

Study of thrombocytopenia in patients of malaria

Gupta¹,

Bansal²,

Jain³

et al. 2013

Trop Parasitol

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Background:Malaria is a Protozoal disease caused by infection with parasites of the genus Plasmodium and transmitted to man by certain species of infected female Anopheline mosquito. In 2008 there were 1.52 million cases of malaria in India, out of which 0.76 million case of Plasmodium falciparum, comprising 50% of total malaria cases. There were 924 deaths from malaria. Hematological abnormalities have been observed in patients with malaria, with anemia, and thrombocytopenia being the most common.Materials and Methods:We conducted this study to find out the frequency and the degree of thrombocytopenia in patients with malaria. In our study, 230 patients with malaria positive were investigated with platelet count.Results:In the study group of 230 patients: 130 (56.51%) were positive for Plasmodium vivax, 90 (39.13%) were positive for P. falciparum and 10 (4.34%) had mixed infection with both P. vivax and P. falciparum. Out of 130 cases detected with vivax malaria, 100 cases had thrombocytopenia. Out of 90 cases detected with falciparum malaria, 70 cases had thrombocytopenia. Among 10 cases of mixed infection, 9 cases had thrombocytopenia.Conclusions:Presence of thrombocytopenia in a patient with acute febrile illness in the tropics increases the possibility of malaria. The above finding can have therapeutic implications in context of avoiding unnecessary platelet infusion in malaria patients.

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Section: Discussionmentioning

confidence: 99%

Study of thrombocytopenia in patients of malaria

Gupta¹,

Bansal²,

Jain³

et al. 2013

Trop Parasitol

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“…Thrombocytopenia is known to complicate malaria (Anstey et al 1992;Butthep & Bunyaratvej 1992;Looareseesuwan et al 1992;Sharma & Das 1992;El Shoura 1993;Inyang et al 1995;Meier et al 1995). Although it can be due to peripheral destruction in the enlarged spleen, there are many reports pointing strongly to an immunological process (Anstey et al 1992;Looareseesuwan et al 1992;Sharma & Das 1992;Meier et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Although it can be due to peripheral destruction in the enlarged spleen, there are many reports pointing strongly to an immunological process (Anstey et al 1992;Looareseesuwan et al 1992;Sharma & Das 1992;Meier et al 1995). However, there are a few reports pointing to other nonimmunological processes (Looareseesuwan et al 1992).…”

Section: Discussionmentioning

confidence: 99%

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Immunoglobulin therapy for severe thrombocytopenia complicating falciparum malaria

Elawad

Jobran

Duya

1999

Tropical Med Int Health

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“…14 Various other studies have shown that thrombocytopenia is equally or even more common in P. vivax malaria contrary to the belief that abnormal haematological parameters is observed in P. falciparum malaria. 15,16,17 More cases of thrombocytopenia in vivax malaria infection may attribute to possible development of a new genotype of P. vivax. 18 Haematological abnormalities like anaemia and thrombocytopenia should increase the possibility of malaria especially when microscopy is negative taking into consideration the life cycle of the parasite.…”

Section: Discussionmentioning

confidence: 99%