Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

Zhang, Hui‐Lu; Yu, Le-Xing; Yang, Wen; Tang, Liang; Lin, Yan; Wu, Han; Zhai, Bo; Tan, Ye-Xiong; Shan, Lei; Liu, Qiong; Chen, Haiyang; Dai, Rongyang; Qiu, Bijun; He, Yaqin; Wang, Chao; Zheng, Liyuan; Li, Yuqiong; Wu, Fengyuan; Li, Zhong; Yan, He‐Xin; Wang, Hongyang

doi:10.1016/j.jhep.2012.06.011

Cited by 242 publications

(245 citation statements)

References 36 publications

(36 reference statements)

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“…Among other antiangiogenic agents with less side effects, blockers of the reninangiotensin system such as angiotensin-I converting enzyme inhibitor and angiotensin-II type 1 blocker have been proved to be promising adjunctive to HCC therapy showing synergistic effects in inhibiting hepatocarcinogenesis (15). Like other two probiotics (8,9), Prohep is now expected to suppress the tumor growth in an orthotopic model. Our concern is not only its effect on angiogenesis and carcinogenesis but also its interactions with other key mediators and various constituent cells in the liver.…”

Section: Authors Next Found That the Proportion Of Th17 Cells In Totamentioning

confidence: 99%

Improve gut microbiome: a new horizon of cancer therapy

Fukui¹

2017

Hepatobiliary Surg. Nutr.

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Section: Authors Next Found That the Proportion Of Th17 Cells In Totamentioning

confidence: 99%

Improve gut microbiome: a new horizon of cancer therapy

Fukui¹

2017

Hepatobiliary Surg. Nutr.

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“…The results showed that translocation of gut organisms to mesenteric lymph nodes was increased in patients with advanced cirrhosis and was reduced to the level found in non-cirrhotic patients by selective intestinal decontamination. There was also evidence showing that gut microbiota might promote liver fibrosis in mice, and the increase in bacterial translocation from gut to liver was associated with chemically induced fibrosis [19]. …”

Section: Roles Of Gut Microbiota In Hepatocarcinogenesismentioning

confidence: 99%

“…Thus, enhanced intestinal permeability to endotoxins appears to be the primary cause of chemically induced endotoxemia. This finding was supported by the fact that reduction of LPS using antibiotics in rats or genetic ablation of its receptor TLR4 in mice dramatically mitigated enteric dysbiosis, decreased liver tumor growth and prevented tumor multiplicity [19]. Yu et al [39] suggested that reducing gut injury, improving blood flow to the gastrointestinal tract and lessening the gut translocation of endotoxin might improve liver function.…”

Section: Roles Of Gut Microbiota In Hepatocarcinogenesismentioning

confidence: 99%

Gut Microbiota and Hepatocellular Carcinoma

Tao

Wang

Qin

2015

Gastrointest Tumors

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Background: Hepatocellular carcinoma (HCC) is a common complication of liver diseases such as those related to viral hepatitis and liver cirrhosis. The gut-liver axis is gaining increasing attention as a key pathophysiological mechanism responsible for the progression of HCC. Here, we will review the data from the published literature to address the association between HCC and gut microbiota. Summary: The presence of high levels of endotoxemia in the blood results in portal hypertension and ensuing hepatocyte damage, thus leading to the development of HCC. Probiotics can be used to treat or prevent the progression of HCC, because they may decrease the counts of gut microbiota and thus improve the endotoxemia. Key Message: Increased bacterial translocation can result in endotoxemia, which may play a critical role in the progression of HCC. Modulation of the gut microbiota by probiotics may represent a new avenue for therapeutic intervention in HCC. Practical Implications: Breakdown in intestinal barrier function and bacterial overgrowth are main events in the development of HCC. When the intestinal barrier function is disrupted, large amounts of bacterial products can enter the liver and induce inflammation through their receptors, leading to liver diseases. Altering the gut microflora has been proposed as an adjunctive therapy to reduce bacterial translocation and prevent progression of HCC. The purpose of this review is to discuss the relationship between gut microbiota and HCC in both pathogenesis and treatment by probiotics.

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“…20 In rat models of hepatocarcinogenesis, induction of gut dysbiosis significantly promoted carcinogenesis. 21 Another report indicates that microbiota may not be involved in initiation of hepatocellular carcinoma but in promotion and proliferation of hepatocellular carcinoma. 22 Changes in microbiota have also been implicated in causation of hepatic encephalopathy, but the reports are conflicting.…”

Section: Microbiota and Liver Diseasementioning

confidence: 99%