Profound haemodilution during normothermic cardiopulmonary bypass influences neither gastrointestinal permeability nor cytokine release in coronary artery bypass graft surgery

Berger, Katharina; Sander, Michael; Spies, C.; Weymann, Lisa; Bühner, Sabine; Lochs, Herbert; Wernecke, Klaus‐D.; Heymann, Christian von

doi:10.1093/bja/aep201

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…Whereas the effect of CPB on clearance was quite obvious, we did not observe an effect of CPB initiation on volume of distribution, although the priming of the bypass circuit with crystalloids causes haemodilution, 22 which was also indicated by the decrease in haematocrit in the present study (Table 2). However, changes in the central volume of distribution have been shown to balance out quickly by redistribution of sufentanil from peripheral compartments.…”

Section: Discussionsupporting

confidence: 40%

Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass

Jeleazcov

Saari

Ihmsen

et al. 2012

British Journal of Anaesthesia

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Section: Discussionsupporting

confidence: 40%

Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass

Jeleazcov

Saari

Ihmsen

et al. 2012

British Journal of Anaesthesia

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“…Moreover, the cytokine interleukin-6 (IL-6) can influence the HPA axis directly by stimulating the glucocorticoid release on the adrenal glands [43,44]. The release of IL-6 usually starts within 60 min after surgical procedures [45,46] and positively correlates with the corticosterone concentration [43,47]. In conclusion, the long-lasting corticosterone response after surgery might arise from the summation of distress parameters that influence the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics

Kumstel

Tang

Zhang

et al. 2019

Animals

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Comparative studies for evaluating distress in established animal models are still rare. However, this issue is becoming more important as a consequence of worldwide appreciation of animal welfare. One good parameter for evaluating distress is the quantification of corticosterone. We hypothesized that not just the absolute value but also the duration of increased corticosterone concentration in the blood is an important aspect for evaluating animal distress. Therefore, we analyzed plasma corticosterone concentrations 30, 60, 120, and 240 min after induction of pancreatitis by cerulein, liver damage by carbon tetrachloride, liver damage by bile duct ligation, and after orthotopic injection of pancreatic cancer cells. We also evaluated corticosterone kinetics after injection of distinct carrier substances. Compared to phosphate buffered saline, dimethyl sulfoxide leads to dose-dependent higher and longer-lasting circulating corticosterone concentrations. In all disease models, we observed significantly increased corticosterone concentration 30 min after stress induction. However, the corticosterone kinetics differed among the animal models. Both the absolute value of corticosterone concentration and the duration correlated positively with the quantification of animal distress by a score sheet. This suggests that both variables of corticosterone kinetics might provide a solid basis for comparing and grading distress of different animal models.

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“…Transfusion triggers for the study groups were determined from information obtained from previous studies that showed that hematocrit values as low as 22% are safe in cardiac surgery with cardiopulmonary bypass. 14,15 Patients assigned to the liberal-strategy group received RBC transfusions if the hematocrit was less than 30% at any time from the start of surgery until discharge from the ICU. Patients assigned to the restrictivestrategy group received RBC transfusions if hematocrit values were less than 24%.…”

Section: Study Design and Treatment Strategiesmentioning

confidence: 99%

Transfusion Requirements After Cardiac Surgery

Hajjar¹,

Vincent²,

Galas³

et al. 2010

JAMA

931

617

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ARDIAC SURGERY IS ASSOCIATED with a high rate of allogeneic bloodtransfusion,varyingfrom 40% to 90% in most reports. 1-3 The rationale for perioperative red blood cell (RBC) transfusion is based on the observation that anemia is an independent risk factor for morbidity and mortality after cardiac operations. 4,5 However, transfusions have been associated with high rates of morbidity and mortality in critically ill patients, 6 and some recent studies have shown worse outcomes, including increased occurrence of renal failure and infection, as well as respiratory, cardiac , and neurologic complications, in transfused compared with nontransfused patients after cardiac surgery. 7,8 There is a lack of evidence regarding optimal blood transfusion practice in patients undergoing cardiac surgery. 9 On See also pp 1568 and 1610.

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Profound haemodilution during normothermic cardiopulmonary bypass influences neither gastrointestinal permeability nor cytokine release in coronary artery bypass graft surgery

Cited by 11 publications

References 25 publications

Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass

Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass

Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics

Transfusion Requirements After Cardiac Surgery

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