2021
DOI: 10.1038/s41597-021-00948-1
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Profiling the small non-coding RNA transcriptome of the human placenta

Abstract: Proper functioning of the human placenta is critical for maternal and fetal health. While microRNAs (miRNAs) are known to impact placental gene expression, the effects of other small non-coding RNAs (sncRNAs) on the placental transcriptome are not well-established, and are emerging topics in the study of environmental influence on fetal development and reproductive health. Here, we assembled a cohort of 30 placental chorionic villi samples of varying gestational ages (M ± SD = 23.7 ± 11.3 weeks) to delineate t… Show more

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Cited by 7 publications
(2 citation statements)
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“…The role of sncRNAs has been extensively researched in various cancer subtypes, with several studies showing their expression levels to be altered in malignant tissue ( Ferreira and Esteller 2018 ). SncRNA transcriptome profiling of placentas ranging from early gestation to term revealed that microRNAs (miRNAs) were the most abundant sncRNA species, followed by Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), and finally transfer RNAs (tRNAs) ( Martinez et al, 2021a ). SncRNA species are potential disease biomarkers or clinically actionable targets—for example, miRNA hsa-miR-16 can directly downregulate the VEGF gene, which is vital in establishing and maintaining the placental vasculature, by binding specifically to its 3’ untranslated region (UTR) ( Zhu et al, 2016 ).…”
Section: Sncrna Expression Impacts Placental Functionmentioning
confidence: 99%
“…The role of sncRNAs has been extensively researched in various cancer subtypes, with several studies showing their expression levels to be altered in malignant tissue ( Ferreira and Esteller 2018 ). SncRNA transcriptome profiling of placentas ranging from early gestation to term revealed that microRNAs (miRNAs) were the most abundant sncRNA species, followed by Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), and finally transfer RNAs (tRNAs) ( Martinez et al, 2021a ). SncRNA species are potential disease biomarkers or clinically actionable targets—for example, miRNA hsa-miR-16 can directly downregulate the VEGF gene, which is vital in establishing and maintaining the placental vasculature, by binding specifically to its 3’ untranslated region (UTR) ( Zhu et al, 2016 ).…”
Section: Sncrna Expression Impacts Placental Functionmentioning
confidence: 99%
“…Maternal viral infection, such as infection of the enveloped ribonucleic acid (RNA) single-stranded Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), during pregnancy is a risk factor for pregnancy complications, neonatal and fetal complications, and long-term health issues [4,5]. Placental gene expression profiling (placental transcriptomics) studies have revealed evidence of differential expression at different stages of a placenta's development, physiology, and pathology [6][7][8][9][10]. Typically, genes are categorized into gene families or gene groups based on a variety of characteristics, including shared protein sequences and function [11].…”
Section: Introductionmentioning
confidence: 99%