Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease

Wu, Delong; Zhao, Baotian; Xie, Hutao; Xu, Yichen; Yin, Zixiao; Bai, Yutong; Fan, Houyou; Zhang, Quan; Liu, Defeng; Hu, Tianqi; Jiang, Yin; An, Q.; Zhang, Xin; Yang, Anchao; Zhang, Jianguo

doi:10.3389/fnagi.2023.1114466

Cited by 2 publications

(1 citation statement)

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“…Four patients with young-onset PD (age of onset<50) were included in the analysis, who could have different clinical features and basal ganglia electrophysiological profiles from late-onset PD. 40 While since most comparisons were made using a within-subject design, its impact on the validity of conclusions should be minor. Third, event-related analysis on the dream-enactment event was not conducted due to the limited number of events captured.…”

Section: Movement Disordersmentioning

confidence: 99%

Contribution of basal ganglia activity to REM sleep disorder in Parkinson’s disease

Yin,

Yuan,

Yang

et al. 2024

J Neurol Neurosurg Psychiatry

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BackgroundRapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common sleep problems and represents a key prodromal marker in Parkinson’s disease (PD). It remains unclear whether and how basal ganglia nuclei, structures that are directly involved in the pathology of PD, are implicated in the occurrence of RBD.MethodHere, in parallel with whole-night video polysomnography, we recorded local field potentials from two major basal ganglia structures, the globus pallidus internus and subthalamic nucleus, in two cohorts of patients with PD who had varied severity of RBD. Basal ganglia oscillatory patterns during RBD and REM sleep without atonia were analysed and compared with another age-matched cohort of patients with dystonia that served as controls.ResultsWe found that beta power in both basal ganglia nuclei was specifically elevated during REM sleep without atonia in patients with PD, but not in dystonia. Basal ganglia beta power during REM sleep positively correlated with the extent of atonia loss, with beta elevation preceding the activation of chin electromyogram activities by ~200 ms. The connectivity between basal ganglia beta power and chin muscular activities during REM sleep was significantly correlated with the clinical severity of RBD in PD.ConclusionsThese findings support that basal ganglia activities are associated with if not directly contribute to the occurrence of RBD in PD. Our study expands the understanding of the role basal ganglia played in RBD and may foster improved therapies for RBD by interrupting the basal ganglia-muscular communication during REM sleep in PD.

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Section: Movement Disordersmentioning

confidence: 99%