Profiling the effect of micronutrient levels on vital cardiac markers

Abstract

Cardiovascular diseases (CVD) are among the most preventable chronic disorders accounting for about one-third of general mortality around the globe. Micronutrients have been shown to have a significant impact on cardiovascular health. Micronutrients have been looked at as the most adoptable lifestyle choice which could reduce the burden of disease around the world. In this context, it is important to study the levels of micronutrients and see their correlation to cardiac disease biomarkers. The present study has attempted to investigate the relationship between the diverse class of micronutrients and serum levels of the key lipids and lipoproteins. A retrospective analysis was carried out between the serum levels of micronutrients and vital cardiovascular markers. The study was carried out in a group of 358 individuals tested for the Cardio Health and Micronutrients Panel at Vibrant America Clinical Laboratory. The study population was categorized based on the serum concentration of lipids and lipoproteins into 3 groups ‘Low’ ‘Normal’ and ‘High’ and the levels of micronutrients were compared among these groups. The results revealed a significant association of several cardiovascular markers with vitamins including Vit D, Vit E, Vit K, and minerals including zinc, iron, calcium, magnesium, and amino acids including leucine, isoleucine, and valine. Quantitative analysis by Pearson’s correlation exhibited a negative correlation of asparagine with serum levels of cholesterol and LDL. Amino acids such as cysteine, isoleucine, and valine were found to have a significant negative correlation with HDL. A positive correlation was observed between valine and serum levels of LDL and Apo B. Vitamins such as Vit A, Vit D3, Vit E, and Vit K1 were found to have a strong positive correlation with levels of total cholesterol and triglycerides. The study summarizes micronutrients and modulation of several lipid markers which are critical for the management of cardiovascular diseases. Micronutrients such as vitamins B1, B3, asparagine, and glutamine have a strong positive association, and fat-soluble vitamins, and BCAA has a strong negative association with cardiovascular health