Profiling the differences of gut microbial structure between schizophrenia patients with and without violent behaviors based on 16S rRNA gene sequencing

Chen, Xiacan; Xu, Jiajun; Wang, Hongren; Luo, Jie; Wang, Zheng; Chen, Gang; Jiang, Dan; Cao, Ruochen; Huang, Haolan; Luo, Dan; Xiao, Xiao; Hu, Junmei

doi:10.1007/s00414-020-02439-1

Cited by 24 publications

(12 citation statements)

References 70 publications

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“…Difference in gut microbial taxonomic compositions is another consideration that associates with clinical events. Compared with controls, Chen et al found that aggression-affected ScZ inpatients had a higher abundance of genera Odoribacter , and lower Delftia and Rubrobacter in feces [ 26 ]. However, relative increased abundance of genera Prevotella, whereas reduced abundance of genera Bacteroides , Faecalibacterium , Blautia, Bifidobacterium, Collinsella and Eubacterium_coprostanoligenes were detected in ScZ inpatients with aggression than the cases without in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Gut dysbacteriosis with leaky gut seems to play a vital role in the pathophysiology. Even though there are four animal-based studies revealing the link between aggressive behaviors and gut microbiota [22][23][24][25], only one patient-based clinical study preliminarily pointed to the possible correlation among aggression onset and gut dysbacteriosis [26]. In this study enrolling 42 ScZ patients (26 with violence and 16 without violence) without antipsychotics discontinuation before samples collecting, no significantly statistical difference in fecal microbiota richness, α-diversity and β-diversity were presented between the two groups [26].…”

Section: Discussionmentioning

confidence: 99%

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Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Deng

Wang

et al. 2022

BMC Psychiatry

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Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and clinical profiles underlying aggression in schizophrenia (ScZ). Methods Serum and stool specimens from ScZ inpatients with (ScZ-Ag, 25 cases) and without aggression (NScZ-Ag, 25 cases) were collected. Systemic inflammation, oxidation and leaky gut biomarkers were determined by ELISA, gut microbiota by 16S rRNA sequencing, short-chain fatty acids (SCFAs) by gas chromatography-mass spectrometry analysis and neurotransmitters by liquid chromatograph mass spectrometry analysis. Results Significantly higher systemic pro-inflammation, pro-oxidation and leaky gut biomarkers were observed in ScZ-Ag than NScZ-Ag group (all P<0.001). Compared to NScZ-Ag group, the alpha-diversity and evenness of fecal bacterial community were much lower, the abundance of fecal genera Prevotella was significantly increased, while that Bacteroides, Faecalibacterium, Blautia, Bifidobacterium,Collinsella and Eubacterium_coprostanoligenes were remarkably reduced in ScZ-Ag group (all corrected P<0.001). Meanwhile, 6 SCFAs and 6 neurotransmitters were much lower in ScZ-Ag group (all P<0.05). Finally, a few strongly positive or negative correlations among altered gut microbiota, SCFAs, systemic pro-inflammation, leaky gut, pro-oxidation and aggression severity were detected. Conclusions These results demonstrate that pro-inflammation, pro-oxidation and leaky gut phenotypes relating to enteric dysbacteriosis and microbial SCFAs feature the aggression onset or severity in ScZ individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Deng

Wang

et al. 2022

BMC Psychiatry

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“… 78 Furthermore, SCZ patients with or without violent behavior had different GMB profiles, which are highly enriched (phylum Bacteroidetes ) and poorly enriched composition (phylum Actinobacteria ). 70 Hence, in the light of the evidence presented, the GMB has a noticeable association with SCZ symptoms and pathophysiology.…”

Section: Resultsmentioning

confidence: 83%

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review

Singh

Stogios

Smith

et al. 2022

Therapeutic Advances in Psychopharmacology

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Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as obesity and diabetes mellitus, leading to increased mortality. Antipsychotics (APs), which are the mainstay in the treatment of SCZ, increase the risk of these metabolic perturbations. Despite extensive research, the mechanism underlying SCZ pathophysiology and associated metabolic comorbidities remains unclear. In recent years, gut microbiota (GMB) has been regarded as a ‘chamber of secrets’, particularly in the context of severe mental illnesses such as SCZ, depression, and bipolar disorder. In this scoping review, we aimed to investigate the underlying role of GMB in the pathophysiology of SCZ and metabolic alterations associated with APs. Furthermore, we also explored the therapeutic benefits of prebiotic and probiotic formulations in managing SCZ and AP-induced metabolic alterations. A systematic literature search yielded 46 studies from both preclinical and clinical settings that met inclusion criteria for qualitative synthesis. Preliminary evidence from preclinical and clinical studies indicates that GMB composition changes are associated with SCZ pathogenesis and AP-induced metabolic perturbations. Fecal microbiota transplantation from SCZ patients to mice has been shown to induce SCZ-like behavioral phenotypes, further supporting the plausible role of GMB in SCZ pathogenesis. This scoping review recapitulates the preclinical and clinical evidence suggesting the role of GMB in SCZ symptomatology and metabolic adverse effects associated with APs. Moreover, this scoping review also discusses the therapeutic potentials of prebiotic/probiotic formulations in improving SCZ symptoms and attenuating metabolic alterations related to APs.

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“…These studies are in general agreement with Dick's talk. A study by Chen et al [56] who evaluated the gut microbial structure between schizophrenia patients with and without violent behavior reported that violent patients were associated with low abundance of Actinobacteria and Firmicutes at a phylum level. Notable, they reported high abundance of Fusobacteria in violent patients.…”

Section: Translational Researchmentioning

confidence: 99%

Interactions between the environmental and human microbiota in the preservation of health and genesis of disease: symposium report

Ramaboli

Nesengani

Katsidzira

et al. 2022

Current Opinion in Gastroenterology

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Purpose of reviewThe purpose of this symposium was to bring thought leaders in the microbiome from the west to Africa to share their unique experiences with African investigators in order to build the foundations for scientifically rigorous explorations into the African human and environmental microbiome that may explain why disease patterns are different in Africa where the chief killers are infectious diseases, whereas noncommunicable diseases (NCDs) are the major threat to healthcare resources in the developed world. Recent findingsThe application of new high throughput technologies to the investigation of the microbiome and its metabolome has revealed mechanisms whereby a traditional African high fiber diet can suppress NCDs which include colon cancer, inflammatory bowel diseases, obesity, type 2 diabetes and atherosclosis. There is concern that with migration and westernization, NCDs are becoming more common in Africa and that food security is becoming impaired by unbalanced obesogenic foods rather than inadequate food intake. SummaryThere is an urgent need for the formation of combined African-Western research programs to identify what is good and bad in the African diet-microbiome axis to develop strategies to prevent the incidence of NCDs rising to western levels in Africa, at the same time offering novel prevention strategies against the #1 healthcare threat in the developed world.

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Profiling the differences of gut microbial structure between schizophrenia patients with and without violent behaviors based on 16S rRNA gene sequencing

Cited by 24 publications

References 70 publications

Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review

Interactions between the environmental and human microbiota in the preservation of health and genesis of disease: symposium report

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