Profiling The Compendium Of Changes InSaccharomyces cerevisiaeDue To Mutations That Alter Availability Of The Main Methyl Donor S-Adenosylmethionine
McKayla Remines,
Makailyn Schoonover,
Zoey Knox
et al.
Abstract:TheSAM1andSAM2genes encode for S-AdenosylMethionine (AdoMet) synthetase enzymes, with AdoMet serving as the main methyl donor. We have previously shown that independent deletion of these genes alters chromosome stability and AdoMet concentrations in opposite ways inS. cerevisiae. To characterize other changes occurring in these mutants, we grew wildtype,sam1Δ/sam11Δ,andsam21Δ/sam21Δstrains in 15 different Phenotypic Microarray plates with different components, equal to 1440 wells, and measured for growth varia… Show more
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