Profiling of the spatiotemporal distribution, risks, and prioritization of antibiotics in the waters of Laizhou Bay, northern China

Lü, Shuang; Lin, Chunye; Lei, Kai; Xin, Ming; Gu, Xiang; Lian, Maoshan; Wang, Baodong; Liu, Xitao; Ouyang, Wei; He, Mengchang

doi:10.1016/j.jhazmat.2021.127487

Cited by 41 publications

(13 citation statements)

References 79 publications

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“…Compared with algae, the risks induced by sulfonamides to fish were relatively low, suggesting that the sulfonamides may cause little harm to fish in urban rivers. Lu et al also confirmed that fish could almost not be affected by antibiotics in Laizhou Bay [ 39 ]. The anti-inflammatory pharmaceutical IPF, quite to the contrary of sulfonamides, always posed a medium risk to fish.…”

Section: Resultsmentioning

confidence: 96%

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Yan

Zhou

Zhang

et al. 2023

IJERPH

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The occurrence, bioaccumulation, and risks of 11 pairs of pharmaceutical metabolites and their respective parents were investigated in the water, sediment, and fish of an urban river in Nanjing city, China. The results showed that most of the target metabolites and their parents were detected in all water samples, with concentrations ranging from 0.1 ng/L to 72.9 ng/L. In some cases, the concentrations of metabolites in water were significantly higher than their parents, with fold changes reaching up 4.1 in the wet season and 6.6 in the dry season, while in sediment and fish, a lower concentration was observed in most cases. A lowered concentration of detected pharmaceuticals was observed in the dry season when compared to the wet season due to the seasonal variation in pharmaceutical consumption and overflow effluent. The bioaccumulation of pharmaceuticals in different fish tissues were detected with a descending order of overall concentration as gill > brain > muscle > gonad > intestine > liver > blood. In addition, the concentrations of both metabolites and their parents also decreased along the river in two seasons. However, the concentration rates of metabolites and their parents were significantly altered along the river in both water and sediment. The relatively high concentration proportions of the detected pharmaceuticals in water suggested that pharmaceuticals were more likely to apportion in water than in sediment, especially for the metabolites. Meanwhile, the rates of the metabolite/parent pairs between fish and water/sediment were generally lower, indicating the higher excretion capacity of metabolites from fish than their parents. Most of the detected pharmaceuticals had no impact on aquatic organisms. However, the presence of ibuprofen posed a medium risk to fish. Compared to the parents, metabolites showed a relatively low risk value but a high contribution to the total risk. It highlights that metabolites in the aquatic environments cannot be ignored.

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Section: Resultsmentioning

confidence: 96%

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Yan

Zhou

Zhang

et al. 2023

IJERPH

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“…Enormously high concentrations of cipro oxacin in e uents of wastewater treatment plants (14 mg/L) and lakes (6.5 mg/L) have also been reported by Fick et al (2009). In estuarine water and seawater of Laizhou Bay in northern China, cipro oxacin was one of the most dominant antibiotics which contributed to over 70% of the total antibiotic burden (Lu et al 2022). Moreover, by inducing antibiotic resistance (Yang et al 2020), cipro oxacin could cause adverse effects on human health at even low concentrations (ng/L) (Koczura et al 2012;Marchant 2018).…”

Section: Introductionmentioning

confidence: 79%

Effects of ciprofloxacin on turion germination and seedling development in two submerged aquatic plants

Fan

Liu

et al. 2022

Preprint

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Germination and seedling development are crucial processes for plant growth and survival, and asexual propagules are predominant reproduction organs for aquatic plants. Ciprofloxacin is widely detected in both terrestrial and aquatic ecosystems, while studies on its effects on germination and seedling development mainly focused on terrestrial plants. We evaluated effects of ciprofloxacin (0.1, 1, 5 and 10 mg/L) on turion germination and early establishment of two submerged plants species (Potamogeton crispus L and Hydrilla verticillata Royle). Results showed that ciprofloxacin did not impact germination rate and rooting rate of both species. However, 0.1 mg/L ciprofloxacin significantly accelerated germination of H. verticillata while 5-10 mg/L ciprofloxacin significantly delayed rooting process of both species. With rising ciprofloxacin concentrations and prolonging exposure time, seedling tolerance index and root number of both species decreased significantly, and shoot number decreased slightly in P. crispus but kept increasing in H. verticillata, suggesting better tolerance of the later under ciprofloxacin exposure. Root and shoot biomass accumulation of both species was significantly inhibited, which was partially due to ciprofloxacin toxicity on photosynthetic pigments. By integrating the biomarkers including plant antioxidants, lipid peroxidation degree and hydrogen peroxide contents, we found that the holistically toxicological effects of ciprofloxacin on seedlings of both species were enhanced with increasing ciprofloxacin concentrations. Overall, ciprofloxacin impacted turion germination process and harmed early establishment of these two submerged plants, which might suggest adverse effects of ciprofloxacin on the survival and expansion of submerged aquatic plant populations and their restoration effectiveness for degraded aquatic vegetations.

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“…This was probably due to the fact that large aquaculture operations were mainly located in coastal areas. For example, in areas such as Jiaozhou Bay and Laizhou Bay in northern China and the Pearl River Estuary in southern China, antibiotic pollution was primarily associated with the aquaculture industry. Additionally, it was noteworthy that the levels of antibiotic contamination were not consistent with the economies and populations.…”

Section: Results and Discussionmentioning

confidence: 99%

Sources, Environmental Fate, and Ecological Risks of Antibiotics in Sediments of Asia’s Longest River: A Whole-Basin Investigation

Chen

Jiang

Wang

et al. 2022

Environ. Sci. Technol.

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This study conducted the first extensive and comprehensive investigation of the whole-scale sedimentary antibiotic concentration, possible drivers, environmental fate, and potential ecological risks in the Yangtze River. Totally, 20 antibiotics were detected in the sediments. Results revealed that the order of antibiotic abundance in sediment was fluoroquinolones > tetracyclines > macrolides > sulfonamides > amphenicols. The total antibiotic concentrations were 0.10−134.4 ng/g (mean: 11.88 ng/g). Of these, fluoroquinolones and tetracyclines were the two dominant antibiotic categories. The dominant occurrence of fluoroquinolones and tetracyclines in sediments suggested that the distribution coefficient (K d ) was one of the important factors to determine their fate. Correlation analysis demonstrated that antibiotic contamination was largely influenced by the local scale of animal husbandry, and the positive correlation between antibiotics and heavy metals was likely driven by their common source of contamination and the complexation. Environmental risk assessment showed that tetracycline and chlortetracycline exhibited potential risks from medium to high in the Yangtze River, although most of the compounds posed minimal and low risks. This work provided a valuable large-scale data set across the whole Yangtze River and revealed the contamination profile of antibiotics. Mitigation and management measures to reduce antibiotic inputs are needed for the Yangtze River basin.

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Profiling of the spatiotemporal distribution, risks, and prioritization of antibiotics in the waters of Laizhou Bay, northern China

Cited by 41 publications

References 79 publications

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Effects of ciprofloxacin on turion germination and seedling development in two submerged aquatic plants

Sources, Environmental Fate, and Ecological Risks of Antibiotics in Sediments of Asia’s Longest River: A Whole-Basin Investigation

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