Profiling of intact blood proteins by matrix‐assisted laser desorption/ionization mass spectrometry without the need for freezing – Dried serum spots as future clinical tools for patient screening
Abstract:Rationale
To open up new ways for matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS)‐based patient screening, blood serum is the most preferred specimen because of its richness in patho‐physiological information and due to ease of collection. To overcome deleterious freeze/thaw cycles and to reduce high costs for shipping and storage, we sought to develop a procedure which enables MALDI‐MS protein profiling of blood serum proteins without the need for serum freezing.
Methods
Blood sera fr… Show more
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