Profiling of heroin and assignment of provenance by 87Sr/86Sr isotope ratio analysis

DeBord, Joshua; Pourmand, A.; Jantzi, Sarah C.; Panicker, Sini; Almirall, José R.

doi:10.1016/j.ica.2017.07.049

Cited by 19 publications

(18 citation statements)

References 29 publications

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“…higher than the reference value (Table 1), with a 16% RSD reflecting the low but variable Rb present in the solutions evident from the 85 Rb ( Figure 2A). The raw 87 Sr/ 86 Sr ratios of the Rb-doped NIST SRM 987 are markedly higher ( 16 O ratios and all measurements are within error of theoretical linear fractionation trend ( Figure 4A).…”

Section: Assessing the Influence Of Rb On Sr And Rbo On Srosupporting

confidence: 63%

“…It was diluted from a stock solution in double‐distilled 2% HNO 3 for analysis. The NIST standards SRM 1570a ‘spinach leaves’ ( 87 Sr/ 86 Sr 0.70905 ± 0.00002) and SRM 1547 ‘peach leaves’ were dissolved in concentrated double‐distilled HNO 3 , dried down and the residue dissolved in 2% HNO 3 to make stock solutions that could be diluted for analysis. Building on the work of Bolea‐Fernandez et al who used CH 3 F as a reaction gas and who observed that Sr isotope measurements with an Agilent (Santa Clara, CA, USA) 8800 ICP‐MS/MS instrument required external mass bias correction using sample standard bracketing with NIST SRM 987, we systematically analysed interleaved NIST SRM 987 and 1570a throughout all the analytical sessions.…”

Section: Methodsmentioning

confidence: 99%

“…Both the exponential and the power-law fractionation trends plot at slightly higher 87 Sr 16 The results for NIST SRM 1570a spinach leaves (Rb/Sr by weight = 0.23, raw 87 Sr/ 86 Sr = 5.7) and NIST SRM 1547 peach leaves (Rb/Sr = 0.37, raw 87 Sr/ 86 Sr = 8.0) are presented in Table 3. The corrected 87 Sr/ 86 Sr weighted average for NIST SRM 1570a is just outside the standard deviation of the three TIMS measurements reported by DeBord et al 16 As the long-term external errors of 87 Sr/ 86 Sr TIMS measurements are higher than the internal error of a single study, we are confident that our weighted average for NIST SRM 1570a will be within error of composites of high-precision analyses. That the mass bias-corrected 87 Sr/ 86 Sr measurements for the Rb-bearing NIST SRM 1570a are all within error of the accepted values indicates that RbO + had no measurable effect.…”

Section: Assessing the Influence Of Rb On Sr And Rbo On Sromentioning

confidence: 99%

“…The corrected 87 Sr/ 86 Sr weighted average for NIST SRM 1547 is the first reported 87 Sr/ 86 Sr ratio for this reference standard. Also included in Table 2 is the sample standard bracketing correction for both plant standards using adjacent 87 Sr 16 O/ 86 Sr 16 O NIST SRM 987 measurements, which yields a higher error than internal linear correction.…”

Section: Assessing the Influence Of Rb On Sr And Rbo On Sromentioning

confidence: 99%

“…This is achieved using the reaction gas N 2 O, where Sr + reacts with N 2 O and is converted to SrO + , while Rb + , which is in a noble gas electron configuration, does not react. This chemical behaviour allows the Sr isotope ratios to be calculated from the Sr 16 O + ions and the additional laborious chemical separation step required for conventional Sr isotope analysis is eliminated.…”

Section: Introductionmentioning

confidence: 99%

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Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation

Murphy

Allen

Ghidan

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Strontium isotopes are valuable markers of provenance in a range of disciplines. Limited amounts of Sr in low‐mass samples such as insects mean that conventional Sr isotope analysis precludes their use for geographic origins in many ecological studies or in applications such as biosecurity. Here we test the viability of using inductively coupled plasma tandem mass spectrometry (ICP‐MS/MS) with N2O as a reaction gas for accurately determining Sr isotopes in insects with Sr < 100 ng. Methods Strontium isotopes were determined in solution mode using ICP‐MS/MS with 0.14 L/min N2O as a reaction gas to convert Sr+ into SrO+ for in‐line separation of 87Sr from 87Rb. The Sr isotope reference standards NIST SRM 987, NIST SRM 1570a and NIST SRM 1547 were used to assess accuracy and reproducibility. Ten insect species collected from the wild as a proof‐of‐principle application were analysed for Sr concentration and Sr isotopes. Results Using ICP‐MS/MS we show for the first time that internal mass bias correction of 87Sr16O/86Sr16O based on 88Sr16O/86Sr16O works to give for NIST SRM 987 a 87Sr/86Sr ratio of 0.7101 ± 0.012 (RSD = 0.17%) and for NIST SRM 1570a a 87Sr/86Sr ratio of 0.7100 ± 0.009 (RSD = 0.12%), which are within error of the accepted values. The first 87Sr/86Sr ratio of NIST SRM 1547 is 0.7596 ± 0.0014. Strontium analyses were run on 0.8 mL of 0.25–0.5 ppb Sr, which equates to 2–4 ng of Sr. Strontium isotope analysis with a precision of >99.8% can be achieved with in‐line separation of 87Sr from 87Rb at least up to solutions with 25 ppb Rb. Conclusions A minimum of 5 mg of insect tissue is required for Sr isotope analysis. This new ICP‐MS/MS method enables Sr isotope analysis in single insects, allowing population‐scale studies to be feasible and making possible applications with time‐critical uses such as biosecurity.

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Section: Assessing the Influence Of Rb On Sr And Rbo On Srosupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Section: Assessing the Influence Of Rb On Sr And Rbo On Sromentioning

confidence: 99%

Section: Assessing the Influence Of Rb On Sr And Rbo On Sromentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation

Murphy

Allen

Ghidan

et al. 2020

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

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Elemental and Isotopic Analyses in Forensic Sciences

Irrgeher¹,

Bandonienė²,

Draxler³

et al. 2020

Encyclopedia of Analytical Chemistry

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The focus of this work is a comprehensive overview of analytical techniques for elemental and isotopic analyses applied in forensic science (i.e. linking crime scene evidence to a crime by applying analytical techniques). The article provides a short description of the spectroscopic techniques and an overview of selected applications. In addition to general forensics, applications in nuclear forensics, environmental forensics, and food forensics are covered. Selected applications are linked to reviews and selected publications, which should allow for an overview of the current approaches in forensic analytical chemistry. This is an update article of its first version published in 2014 by Prohaska and Draxler. 1

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Structure of heroin in a solution revealed by chiroptical spectroscopy

et al. 2020

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In this work, the 3‐D structure of the well‐known opioid drug heroin in a solution was investigated. The goal was to provide a complete and detailed description of the stable conformers with their relative abundances. This knowledge is very important from the pharmaceutical and forensic point of view as it could help significantly with deeper understanding of heroin's metabolism and the development of antagonist medicines for the case of an overdose. As heroin is a chiral compound with five stereogenic centres, the methods of chiroptical spectroscopy supplemented by density functional theory (DFT) calculations were applied to study its conformations in chloroform solution. The selected chiroptical methods, namely, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD), are inherently sensitive to the 3‐D structure of small‐ to medium‐sized chiral organic molecules. A thorough conformational analysis revealed four stable conformers of heroin in chloroform solution, where the conductor‐like polarizable continuum model of the solvent was used for all the calculations. The simulated ultraviolet (UV), infrared (IR), ECD, and VCD spectra were compared with the experimental ones and very good agreement was found, which enabled a detailed structure description and interpretation of the spectra. Chiroptical spectroscopy in combination with DFT calculations proved to be a very sensitive tool for the analysis of the 3‐D structure of heroin in a solution in contrast with conventional spectroscopic methods. Especially, the application of VCD seems to be a promising approach for monitoring structural changes, for instance, those caused by solvents or interactions with other agents.

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Profiling of heroin and assignment of provenance by 87Sr/86Sr isotope ratio analysis

Cited by 19 publications

References 29 publications

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation

Elemental and Isotopic Analyses in Forensic Sciences

Structure of heroin in a solution revealed by chiroptical spectroscopy

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Profiling of heroin and assignment of provenance by 87Sr/86Sr isotope ratio analysis

Cited by 19 publications

References 29 publications

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N2O as a reaction gas for in‐line Rb separation

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N2O as a reaction gas for in‐line Rb separation

Elemental and Isotopic Analyses in Forensic Sciences

Structure of heroin in a solution revealed by chiroptical spectroscopy

Contact Info

Product

Resources

About

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation

Analysing Sr isotopes in low‐Sr samples such as single insects with inductively coupled plasma tandem mass spectrometry using N₂O as a reaction gas for in‐line Rb separation