Profiling of heavy metal and pesticide residues in medicinal plants

Kumar, Narendra; Kulsoom, Mahiya; Shukla, Vertika; Kumar, Dhananjay; Priyanka, .; Kumar, Sanjeev; Tiwari, Jaya; Dwivedi, Neetu

doi:10.1007/s11356-018-2993-z

Cited by 55 publications

(42 citation statements)

References 23 publications

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“…e traditional plant Vernonia amygdalina is widely used in local communities of Africa (including Uganda) for home-based treatment of noncancer health conditions against bacterial and protozoal infections [3,4], but detailed pharmacological knowledge and information on the presence of elements that could be toxic to humans is scarce. e most notable elements present in most medicinal herbs and vegetables are heavy metals such as lead (Pb), copper (Cu), nickel (Ni), iron (Fe), cobalt (Co), zinc (Zn), chromium (Cr), and cadmium (Cd) [5]. Essential elements include Co, Cu, Fe, and Zn due to their nutritional advantages in the body while nonessential elements include Ni, Pb, Cd, and Cr due to their carcinogenic effects [6].…”

Section: Introductionmentioning

confidence: 99%

“…However, consumption above the safe or acceptable limits is associated with health risks due to heavy metal toxicity [2]. e permissible levels of heavy metals in medicinal plants set by the Joint Food and Agriculture Organization (FAO)-World Health Organization (WHO) committee for Fe, Cu, Cd, Pb, Cr, Co, Ni, and Zn are 20 ppm, 150 ppm, 0.3 ppm, 10 ppm, 2 ppm, 0.48 ppm, 2.14 ppm, and 27.4 ppm, respectively [5,38]. Plants with higher concentrations of heavy metals above these limits are regarded as being unsafe for human consumption and pose major public health risks [2].…”

Section: Introductionmentioning

confidence: 99%

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Consumption of Raw Herbal Medicines Is Associated with Major Public Health Risks amongst Ugandans

Ssempijja

Kasozi

Eze

et al. 2020

Journal of Environmental and Public Health

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Background. Community consumption of herbal plants in developing countries is a common practice, however, scarcity of information on their physiochemical composition is a major public health concern. In Uganda, Vernonia amygdalina is of interest in rural communities due to its therapeutical action on both bacterial and protozoal parasites, however no studies have been conducted to assess the heavy metal concentrations in traditional plants used in alternative medicine. The aim of the study was to establish concentrations of heavy metals in Vernonia amygdalina, model the estimated daily intake (EDI), and assess both the non-cancer-related health risk using the target hazard quotient (THQ), and the risk related to cancer through the incremental lifetime cancer risk (ILCR) for the Ugandan population. Methods. Leaves of Vernonia amygdalina were collected from 20 georeferenced villages and processed into powder in the laboratory using standard methods. These were then analyzed in the laboratory using an atomic absorption spectrometer for lead (Pb), chromium (Cr), copper (Cu), zinc (Zn), cobalt (Co), iron (Fe), cadmium (Cd), and nickel (Ni). Concentrations were compared against the World Health Organization (WHO) limits. The EDI, THQ, and ILCR were modelled and significance was measured at 95% confidence. Results. The study showed that mean ± SEM concentrations of heavy metals were highest in the order of Cr, 121.8 ± 4.291 ppm > Ni, 84.09 ± 2.725 ppm > Zn, 53.87 ± 2.277 ppm > Pb, 40.61 ± 3.891 ppm > Cu, 28.75 ± 2.202 ppm > Fe, 14.15 ± 0.7271 ppm > Co, 7.923 ± 0.7674 ppm > Cd, 0.1163 ± 0.005714 ppm. Concentrations of Pb, Cr, Zn, Co, and Ni were significantly higher than the WHO limits. The EDI was significantly higher in children than in adults, demonstrating an increased risk of toxicity in children. The THQ and ILCR were over 1000 times higher in all Ugandans, demonstrating the undesirable health risks following oral consumption of Vernonia amygdalina due to very high Cr and Ni toxicities, respectively. Conclusion. Consumption of raw Vernonia amygdalina was associated with a high carcinogenic risk, demonstrating a need to enact policies to promote physiochemical screening of herbal medicines used in developing countries against toxic compounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Consumption of Raw Herbal Medicines Is Associated with Major Public Health Risks amongst Ugandans

Ssempijja

Kasozi

Eze

et al. 2020

Journal of Environmental and Public Health

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“…Unfortunately, environmental contamination and pollution entail a decrease in the quality of the plant raw material, which can accumulate not only heavy metals and toxins, but also herbicides, pesticides, and other chemicals that enter plants with water and air [17]. The most frequent contaminants of medicinal plants are pesticide residues, heavy metals, mycotoxins, polycyclic aromatic hydrocarbons and pyrrolizidine alkaloids [18]. Pollution of the environment with heavy metals causes these metals to penetrate plants growing on contaminated soils [19,20].…”

Section: State-of-the-art Knowledgementioning

confidence: 99%

“…Additionally, the exposition of plants to various pesticides can contaminate the plant raw material causing, finally, the negative impact of phytotherapy on human health [18]. Although pesticides protect the plants from deleterious pests, they can also contribute negatively to the possibility of the application of medicinal materials in medicine [44][45][46][47].…”

Section: State-of-the-art Knowledgementioning

confidence: 99%

Prospects for the use of herbal medicines in relation to progressing environmental pollution

Łuszczki¹,

Gustaw-Rothenberg²,

Chmielewski³

et al. 2020

Med Środow.

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Due to the increasing pollution of the natural environment, the amount of impurities that can accumulate in herbs and plants used for therapeutic purposes as medicinal plants also increases. As many plant materials have medicinal properties and have been used as medicinal remedies,they must be subjected to rigorous assessments according to material quality standards.Presently, however, there is no guarantee that there has been no change in the amount and content of medicinal bioactive substances, compared to plants used years ago in traditional folk medicine. At present, there are great prospects in the use of medical plants, especially if the medicinal plants are free from pollution originating from the contaminated natural environment. The attention of researchers should focus not only on seeking new bioactive compounds and finding new drugs in plants, but also on ensuring high standards of quality regarding the evaluation of the chemical purity of plants growing in the environment exposed to contamination and pollution. The combination of both challenges can help patients suffering from increasing numbers of ailments and diseases of civilization. Researchers must also be actively involved in the process of detection any harmful substances penetrating from the environment into plants by applying various biomedical and chemical techniques to detect some novel, as yet unknown threats, in order not to expose patients to them.

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“…Study in mice at all the three level F. indica did not generate any special change in body weight, daily food and water ingestion of rodents when evaluated to medium treated rats. (Kumar et al, 2018). Fumaria indica is a wildly growing weed found in Pakistan and many other region of the world.…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Study of Fumaria Indica Plant From the Hilly and Plain Areas of Haripur

Shaeen

Shah

Rehman

et al. 2020

Preprint

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BackgroundThe purpose of this study was to find out the ethnobotanical use of Fumaria indica plant from the hilly and plain areas of Haripur .MethodsThe plant samples of leaf, flowers and root were collected from two hilly areas (Srikot, Khanpur) and two plane areas (Haripur city, Tarbela) of District Haripur and processed for further analysis process. The preferences of local people for the treatment of various ailments in terms of medicinal plant used, part used, the category of diseases treated and the form of therapeutic use (recipe) were analyzed with the help of a questionnaire survey. The recorded data was tabulated theme wise and Microsoft Excel program was used in the calculation of values and percent references and its presentation in graphic form.ResultsEthnobotanical study showed that the Fumaria indica plant used as a source of medicine in local community, the powder form was used in allergies, fevers and diabetes. The plant was used as a source of medicine and cure many types of bacteria diseases.conclusionFumaria indica & Caesalpinia bonducella are the plants known for their digestive, spasmolytic, diuretic, anthelmintic, hepatoprotective, anti-inflammatory, antipyretic anti dysentery activity.Powder drugs of (leaves, roots and flowers) of Fumaria indica were made for different analyses.

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Profiling of heavy metal and pesticide residues in medicinal plants

Cited by 55 publications

References 23 publications

Consumption of Raw Herbal Medicines Is Associated with Major Public Health Risks amongst Ugandans

Consumption of Raw Herbal Medicines Is Associated with Major Public Health Risks amongst Ugandans

Prospects for the use of herbal medicines in relation to progressing environmental pollution

Ethnobotanical Study of Fumaria Indica Plant From the Hilly and Plain Areas of Haripur

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