Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines

Toxicological Evaluation of Bisphenol A and Its Analogs

“…It is seen to distrupt gene expression by thyroid receptors in vivo and in vitro. 14 In addition to mentioned effects, it is observed that BPA activates PXR from the nuclear receptors, induces CYP3A4 and environmental exposure to BPA can change 25-hydroxy vitamin D level in circulation in adults and there is a negative corelation between BPA and 25(OH)D. 16 In a previous research, it is reported that BPA induces DNA strand breaks in ERpositive MCF-7 cells and its genotoxicity is ER-dependent. It is observed that it induces micronucleus formation and chromosomal aberrations in rat bone marrow, causes DNA damage in lymphocytes.In a different study it is suggested that oxidative stress occurs by observing an increase in 8-hydroxyguanosine plasma levels, an increase in lipit peroxidation, a decrease in glutation activity in liver.…”

“…6 The chemical nomenclature of BPS is bis [4-hydroxyphenyl]sulfone and it has a molecular weight of 250.27 g/mol. 3,16 BPS is a heat resistant structural analog of BPA. 16 It has high thermal stability and it is resistant to sunlight.…”

“…3,16 BPS is a heat resistant structural analog of BPA. 16 It has high thermal stability and it is resistant to sunlight. 16,17 As a member of large and diverse group of bisphenols, BPS is commonly used in numerous consumer products as a replacement of BPA.…”

“…16 It has high thermal stability and it is resistant to sunlight. 16,17 As a member of large and diverse group of bisphenols, BPS is commonly used in numerous consumer products as a replacement of BPA. As being the most commonly used alternative of BPA, BPS is frequently used in production of plastics and thermal papers.…”

“…3,17 BPS is used as improver in thermal papers,stabilizer in canned soft drinks and canned food. 6,16 In addition BPS is used as fastening agent in cleaning products, electroplating solvent, a constituent of epoxy resins in various ındustrial applications. 5 As a commonly used analog of BPA in production, the presence of BPS in nature and food is demonstrated in numerous researches.…”