Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
Moritz Weigl,
Teresa L. Krammer,
Marianne Pultar
et al.
Abstract:In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unmet need for minimally invasive biomarkers of senescent cell load to identify patients at need for senotherapy. We created a landscape of miRNA and mRNA expression in five human cell types induced to senescencein-vitroand provide proof-of-principle evidence that miRNA expressio… Show more
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