Profiling cosmeceutical effects of various herbal extracts through elastase, collagenase, tyrosinase inhibitory and antioxidant assays

Five New Tamarixetin Glycosides from Astragalus thracicus Griseb. Including Some Substituted with the Rare 3-Hydroxy-3-methylglutaric Acid and Their Collagenase Inhibitory Effects In Vitro

“…Flavonoids, and especially the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin . There are numerous reports showing the plant extracts inhibiting collagenase, with flavonoids being assigned to be responsible for the activity. − Also, isolated flavonoids showed the inhibitory effects on collagenase and elastase, given the connections with their possible anti-inflammatory and antiaging activities. − For example, Shaji et al documented the ability of tamarixetin to inhibit matrix metalloproteinase-9 (also known as 92 kDa type IV collagenase) via inhibition of the nuclear factor κB pathway . Further, inhibition of this cellular pathway leads to a decrease of expression of proinflammatory cytokines.…”

“…Flavonoids, and especially the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin. 27 There are numerous reports showing the plant extracts inhibiting collagenase, with flavonoids being assigned to be responsible for the activity. 28−30 Also, isolated flavonoids showed the inhibitory effects on collagenase and elastase, given the connections with their possible anti-inflammatory and antiaging activities.…”

Chemical Profiling and Enzyme Inhibitory Activities of Essential Oil Isolated from Pistacia khinjuk Leaves: Insights On GC‐MS Analysis and Skin Aging‐Relevant Enzymes

“…[45] With agreement of our findings, other Pistacia species namely, Pistacia vera moderately inhibited collagenase (~50.33 %). [49] Also, Pistacia atlantica were reported to have in vitro antioxidant properties which prevent oxidative stress during aging. [50] Further, one of the famous edible plants of this family is cashew tree (Anacardium occidentale L.), which showed powerful antioxidant activities, antityrosinase and ant collagenase properties at low concentration of extract.…”

“…[41] With agreement of earlier study, an in vitro study reported anti-elastase activity at concentration of 666 μg/mL with an inhibition value of ~64.33 %. [49] Numerous studies have correlated the increased oxidative stress with skin aging . [55] Generally, reactive oxygen species (ROS) is generated from mitochondria, peroxisomes, cytosolic enzymes as a result of intracellular metabolism.…”

Citrus reticulata Leaves Essential Oil as an Antiaging Agent: A Comparative Study between Different Cultivars and Correlation with Their Chemical Compositions

“…Currently, the use of natural ingredients in cosmetics is widely spread compared with the synthetic alternative, due to their wide safety margin, potential antioxidant, anti-inflammatory, and skin soothing effects. Interestingly, many of the commercial and medical skin aging creams contain essential oils, herbal extracts, and other natural ingredients which meet the increased demand in the market for herbal-based cosmetics [ 34 ]. Moreover, the promising antioxidant activity of various citrus essential oils encouraged us to study the anti-collagenase, anti-hyaluronidase, and anti-elastase capabilities to prove their antiaging potential in an attempt incorporate it safely as a natural ingredient in management of age-related skin problem [ 35 , 36 , 37 ].…”