Profiling Cellular Morphological Changes Induced by Dual‐Targeting PROTACs of Aurora Kinase and RNA‐Binding Protein YTHDF2
Georg L. Goebel,
Nicole Giannino,
Philipp Lampe
et al.
Abstract:Proteolysis targeting chimeras (PROTACs) are new chemical modalities that degrade proteins of interest, including established kinase targets and emerging RNA‐binding proteins (RBPs). Whereas diverse sets of biochemical, biophysical and cellular assays are available for the evaluation and optimizations of PROTACs in understanding the involved ubiquitin‐proteasome‐mediated degradation mechanism and the structure‐degradation relationship, a phenotypic method profiling the cellular morphological changes is rarely … Show more
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