Profiling canine mammary tumors: A potential model for studying human breast cancer

Gherman, Luciana-Madalina; Chiroi, Paul; Nuţu, Andreea; Bica, Cecilia; Berindan-Neagoe, Ioana

doi:10.1016/j.tvjl.2023.106055

The Veterinary Journal

2024

DOI: 10.1016/j.tvjl.2023.106055

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Profiling canine mammary tumors: A potential model for studying human breast cancer

Luciana-Madalina Gherman,

Paul Chiroi,

Andreea Nuţu

et al.

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Molecular Markers in Canine Mammary Tumors

Gherman,

Isachesku,

Zanoaga

et al. 2024

Acta Veterinaria

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Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, the current diagnosis often occurs in later stages, and there is a pressing need for more comprehensive data on treatment options to improve overall prognosis. Consequently, the early detection of these tumors is critical for improving treatment outcomes and survival rates. As such, biomarkers are essential for improving the diagnosis, treatment, and prognosis of CMT, the reason for which further research is required to enhance our understanding of the disease. The most studied biomarkers for CMT are evaluated from serum and tissue samples using different molecular approaches and relate to proliferation and cell cycle. Several biomarkers were also described regarding cell damage, autophagy and apoptotic-related pathways, hypoxia, angiogenesis, EMT, invasion, metastasis or cancer stem features. Overall, biomarkers have shown the potential to be used as a tool for the early detection of mammary tumors in dogs. However, more research is needed to validate these biomarkers and to develop sensitive and specific diagnostic tests. In this regard, we aimed to review known biomarkers and their role in CMT comprehensively. We also encouraged further investigations of reliable biomarkers that could improve treatment outcomes and survival rates for dogs with this disease.

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Molecular Markers in Canine Mammary Tumors

Gherman,

Isachesku,

Zanoaga

et al. 2024

Acta Veterinaria

Self Cite

View full text Add to dashboard Cite

show abstract

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Profiling canine mammary tumors: A potential model for studying human breast cancer

Cited by 1 publication

References 151 publications

Molecular Markers in Canine Mammary Tumors

Molecular Markers in Canine Mammary Tumors

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