Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma

Wang, Zheyuan; Shi, Zhiheng; Zhang, Lu; Zhang, Huihan; Zhang, Yawu

doi:10.1016/j.prp.2018.12.012

Cited by 22 publications

(17 citation statements)

References 14 publications

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“…However, the mechanism of miRNAs in aging-induced BMSCs differentiation during osteoporosis remains limited. MiR-19a-3p is a members of the miR-17-92 cluster, and usually reported as oncogene in various cancers, including lung cancer [13,20], colorectal cancer [21], breast cancer [10], hepatocellular carcinoma [12] and cervical cancer [22]. Studies also showed that miR-19a-3p involved in the vascular inflammation of atherosclerosis [7] and involved in the epithelium repair of asthma by regulating proliferation of bronchial epithelial cells [23].…”

Section: Discussionmentioning

confidence: 99%

“…It was reported to participate in the pathogenesis of preeclampsia and atherosclerosis [7,8]. A recent study has demonstrated the involvement of miR-19a-3p in the progression of various cancers including glioma, lung cancer, breast cancer, osteosarcoma, gastric cancer and hepatocellular carcinoma [9][10][11][12][13]. However, the precise mechanism by which miR-19a-3p in aging-induced osteoporosis remains unknown.…”

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confidence: 99%

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lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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The switch between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a key role in aging-induced osteoporosis. In this study, miR-19a-3p was obviously downregulated in BMSCs from aged humans and mice. Overexpressed miR-19a-3p evidently reduced aginginduced bone loss in mice and promoted osteogenic differentiation of BMSCs, while silenced miR-19a-3p manifestly increased aging-induced bone loss in mice and repressed osteogenic differentiation of BMSCs. Hoxa5 was significantly downregulated in the BMSCs from aged mice and contribute to miR-19a-3p-induced osteoblast differentiation as a direct target gene of miR-19a-3p. Furthermore, lncRNA Xist was found as a sponge of miR-19a-3p to repress BMSCs osteogenic differentiation. In conclusion, our study reveals the critical role of the lncRNA Xist/miR-19a-3p/Hoxa5 pathway in aging-induced osteogenic differentiation of BMSCs, indicating the potential therapeutic target for osteoporosis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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“…In addition to its sequestering function on actin monomers, PROF1 promotes the assembly of globular-actin monomers (G-actin) into filamentous-actin (F-actin) (210), interacts with certain membrane lipids, and is also involved in regulating the expression of several cancer stem cell genes (211). PROF1 has been shown to be downregulated in different types of cancer, including breast, pancreatic and hepatocellular carcinoma, and it is associated with aggressive clinicopathological characteristics and a poor prognosis (212).…”

Section: Cytoskeletonmentioning

confidence: 99%

Biomarkers of tumor invasiveness in proteomics (Review)

et al. 2020

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Over the past two decades, quantitative proteomics has emerged as an important tool for deciphering the complex molecular events involved in cancers. The number of references involving studies on the cancer metastatic process has doubled since 2010, while the last 5 years have seen the development of novel technologies combining deep proteome coverage capabilities with quantitative consistency and accuracy. To highlight key findings within this huge amount of information, the present review identified a list of tumor invasive biomarkers based on both the literature and data collected on a biocollection of experimental cell lines, tumor models of increasing invasiveness and tumor samples from patients with colorectal or breast cancer. Crossing these different data sources led to 76 proteins of interest out of 1,245 mentioned in the literature. Information on these proteins can potentially be translated into clinical prospects, since they represent potential targets for the development and evaluation of innovative therapies, alone or in combination. Herein, a systematical review of the biology of each of these proteins, including their specific subcellular/extracellular or multiple localizations is presented. Finally, as an important advantage of quantitative proteomics is the ability to provide data on all these molecules simultaneously in cell pellets, body fluids or paraffin-embedded sections of tumors/invaded tissues, the significance of some of their interconnections is discussed.

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“…[24][25][26] For example, it enhances the multiplication, metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma cells through specifically regulating Profilin 1. 27 In breast cancer, miR-19a-3p inhibits Fra-1 proto-oncogene expression, which in turn induces macrophage polarization and inhibits the growth of tumor cells. 28 In CRC, miR-19a-3p expression is Consistently, in the present study, we confirmed that miR-19a-3p directly targeted FOXF2 and negatively modulated its expression.…”

Section: Discussionmentioning

confidence: 99%

lncRNA MCM3AP‐AS1 inhibits the progression of colorectal cancer via the miR‐19a‐3p/FOXF2 axis

Dai

Zeng

Lee

2021

The Journal of Gene Medicine

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Background Long non‐coding RNA MCM3AP antisense RNA 1 (lncRNA MCM3AP‐AS1) has a regulatory role in the development of diverse malignancies, whereas its role and mechanism in colorectal cancer (CRC) is not yet clear. Methods The relative expression of MCM3AP‐AS1, miR‐19a‐3p and forkhead box F2 (FOXF2) mRNA in 53 cases of CRC and its adjacent normal tissues, human normal colonic mucosal cells (FHC cells) and CRC cell lines was examined by a quantitative real‐time polymerase chain reaction, and the changes of cell multiplication and migration were examined by the cell counting kit‐8 method, EdU test, and scratch‐healing test, respectively. Bioinformatics, dual‐luciferase reporter gene assay and a RNA immunoprecipitation experiment were adopted to predict and verify the relationship between MCM3AP‐AS1 and miR‐19a‐3p; bioinformatics and dual‐luciferase reporter gene assay were adopted to predict and verify the relationship between miR‐19a‐3p and FOXF2. Western blotting was executed to examine the effects of MCM3AP‐AS1 overexpression or knockdown on FOXF2 protein expression. Results MCM3AP‐AS1 expression was down‐modulated in CRC, and its dysregulation was linked to unfavorable pathological characteristics. MCM3AP‐AS1 significantly impeded the multiplication and migration of CRC cells. MCM3AP‐AS1 was recognized as a molecular sponge to suppress miR‐19a‐3p expression, and FOXF2 was a target gene of miR‐19a‐3p. MCM3AP‐AS1 positively modulated FOXF2 expression, and its biological effect was dependent the on miR‐19a‐3p/FOXF2 axis. Conclusions MCM3AP‐AS1 can inhibit CRC promoting by modulating the miR‐19a‐3p/FOXF2 axis.

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Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma

Cited by 22 publications

References 14 publications

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Biomarkers of tumor invasiveness in proteomics (Review)

lncRNA MCM3AP‐AS1 inhibits the progression of colorectal cancer via the miR‐19a‐3p/FOXF2 axis

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