2021
DOI: 10.1007/s11011-021-00788-3
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Profiles of urine and blood metabolomics in autism spectrum disorders

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Cited by 31 publications
(29 citation statements)
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“…Similarly, in depression, metabolomic techniques have been used to identify differential metabolites and mechanisms of action for antidepressants 15 . In the context of ASD, researchers have observed notable disparities in the abundance of metabolites present in the serum and urine of individuals with ASD compared to typically developing children 16–18 . Using mass spectrometry techniques, Needham et al.…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, in depression, metabolomic techniques have been used to identify differential metabolites and mechanisms of action for antidepressants 15 . In the context of ASD, researchers have observed notable disparities in the abundance of metabolites present in the serum and urine of individuals with ASD compared to typically developing children 16–18 . Using mass spectrometry techniques, Needham et al.…”
Section: Introductionmentioning
confidence: 99%
“…Several dozen autism gut metagenomics studies have revealed many, albeit inconsistent, variations in microbial diversity in individuals with ASD compared with neurotypical individuals [18, 19, 17]. Similarly, metagenome-based functional reconstructions and metabolic analyses have also shown strong, albeit inconclusive differences between ASD and neurotypical individuals [20, 21, 22]. Comparative analyses at other omic levels have further shown little agreement across studies [23] raising the question of whether the results obtained so far reflect intrinsic biological differences among cohorts, insufficient statistical power, or experimental biases that preclude meaningful comparisons [24].…”
Section: Introductionmentioning
confidence: 99%
“…As for ASD, serum and urine metabolomics have identified biomarkers attributable to gut dysmicrobism, amino acid metabolism, and mitochondrial dysfunction [ 19 , 20 ] while, regarding PANS and metabolomics, this field appears to not be sufficiently explored, with little reported evidence [ 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%