Profiles of urinary neonicotinoids and dialkylphosphates in populations in nine countries

Li, Adela Jing; Kannan, Kurunthachalam

doi:10.1016/j.envint.2020.106120

Cited by 64 publications

(34 citation statements)

References 43 publications

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“…Wang et al (2020) reported a low detection frequency of 38% for ACE in tandem with 96.6% detection frequency for dm‐ACE in a Chinese population. Li and Kannan (2020) and Ospina et al (2019) reported high detection rates for dm‐ACE in human subjects from various countries across the world, but their study did not detect ACE in any of their target population. Meanwhile, the detection frequency and median concentrations of ACE recorded within the present study population (2.67% and <LOQ, respectively) were far lower than what was previously reported for a Japanese population (detection frequency 56%, median concentration 0.02 µg/L [Ueyama et al 2014]) and a Chinese population (detection frequency 96%, median concentration 0.014 µg/L [Zhang et al 2019]).…”

Section: Resultsmentioning

confidence: 90%

“…Imidacloprid was predominantly detected in 70.7% of the present study population, with a mean concentration of 2.794 ± 19.01 µg/L (1.09 ± 4.90 µg/g Cre) and a range of <LOQ to 165.01 µg/L (<LOQ–42.00 µg/g Cre). Several biomonitoring studies have similarly reported a high detection frequency of >70% for IMI in various human populations across the world (Ueyama et al 2015; Honda et al 2019; Zhang et al 2019; Li and Kannan 2020; Wang et al 2020). In the present study, the maximum concentration of IMI recorded among the study population (165.01 µg/L, 42.00 µg/g Cre) far exceeded those recorded for all the other detected NNIs.…”

Section: Resultsmentioning

confidence: 98%

“…Ueyama et al (2015) detected NIT in a Japanese population with a low frequency of 29%, but their study did not detect NIT metabolites such as CPMA and CPMF. Perhaps, previous human biomonitoring studies (Zhang et al 2019; Li and Kannan 2020; Wang et al 2020) failed to detect NIT metabolites (CPMF and CPMA) in human urine because of analytical constraints or a lack of appropriate standards.…”

Section: Resultsmentioning

confidence: 99%

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Human Exposures to Neonicotinoids in Kumasi, Ghana

Nimako

Ikenaka

Akoto

et al. 2021

Enviro Toxic and Chemistry

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Neonicotinoid insecticides (NNIs) are now popular in many agricultural systems across Africa; however, the extent of human exposures to NNIs in African countries is scarcely reported. The present study evaluates neonicotinoid exposures in the consumer population of Kumasi, a cosmopolitan city in Ghana. A total of 75 human urine samples were collected from healthy volunteers (nonfarmers, aged 13-80 yr) and analyzed with a liquid chromatography electrospray ionization tandem mass spectrometry system. Seven NNIs and 3 NNI metabolites were detected in the following pattern (frequency, median concentration, maximum concentration): N-dm-acetamiprid (94.7%, 0.41 µg/L, 8.79 µg/L) > imidacloprid (70.7%, 0.15 µg/L, 211.62 µg/L) > N-(6-chloro-3-pyridylmethyl)-N-ethyl-N′-methylformamidine (62.2%, 0.43 µg/L, 53.85 µg/L) > 2-[N-(6-chloro-3pyridylmethyl)-N-ethylamino]-2-(methylimino)acetic acid (56.8%, 0.10 µg/L, 3.53 µg/L) > clothianidin (40%, >limit of quantification [LOQ], 0.45 µg/L) > nitenpyram (18.7%, >LOQ, 0.14 µg/L) ≈ thiamethoxam (18.7%, >LOQ, 0.21 µg/L) > dinotefuran (12.0%, >LOQ, 1.01 µg/L) > acetamiprid (2.7%, >LOQ, 0.08 µg/L) ≈ thiacloprid (2.7%, >LOQ, 0.14 µg/L). Approximately 92% of the subjects were found to be exposed to multiple neonicotinoids simultaneously. The mean, median, and maximum imidacloprid equivalent of the relative potency factor of NNIs were found to be 1.6, 0.5, and 22.52, respectively. The median estimated daily intakes of acetamiprid, imidacloprid, and nitenpyram were 0.47, 1.27, and 0.02 µg/kg/d for females and 0.91, 0.66, and 0.08 µg/kg/d for males, respectively. The maximum daily intakes of all the NNIs were <1% of their chronic reference doses (cRfDs), except for imidacloprid and thiacloprid which recorded maximum daily intakes corresponding to 17.97 and 8.28% of cRfDs, respectively. To the best of our knowledge, the present study is the first biomonitoring report on neonicotinoid insecticides in Africa.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Human Exposures to Neonicotinoids in Kumasi, Ghana

Nimako

Ikenaka

Akoto

et al. 2021

Enviro Toxic and Chemistry

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“…For mice, treated with NOAEL levels of Imida and Aceta (10 mg/kg), the brain levels were around 3–6 ppm, and plasma concentrations were in a similar range (15–30 µM) (Ford and Casida 2006 ). Human data are mostly available for urinary metabolites used for biomonitoring, and the concentrations were maximally in the low nM range (Zhang et al 2019 ; Li et al 2020 ; Li and Kannan 2020 ). Due to the lack of more direct data, we built physiology-based toxicokinetic (PBTK) models to predict plasma and brain concentrations (Table S11).…”

Section: Resultsmentioning

confidence: 99%

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

et al. 2021

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Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signaling. In parallel, we profiled dopaminergic neurons, generated from LUHMES neuronal precursor cells, as novel system to study nAChR activation in human post-mitotic neurons. Changes of the free intracellular Ca2+ concentration ([Ca2+]i) were used as readout, and key findings were confirmed by patch clamp recordings. Nicotine triggered typical neuronal signaling responses that were blocked by antagonists, such as tubocurarine and mecamylamine. Pharmacological approaches suggested a functional expression of α7 and non-α7 nAChRs on LUHMES cells. In this novel test system, the neonicotinoids acetamiprid, imidacloprid, clothianidin and thiacloprid, but not thiamethoxam and dinotefuran, triggered [Ca2+]i signaling at 10–100 µM. Strong synergy of the active neonicotinoids (at low micromolar concentrations) with the α7 nAChR-positive allosteric modulator PNU-120596 was observed in LUHMES and SH-SY5Y cells, and specific antagonists fully inhibited such signaling. To provide a third line of evidence for neonicotinoid signaling via nAChR, we studied cross-desensitization: pretreatment of LUHMES and SH-SY5Y cells with active neonicotinoids (at 1–10 µM) blunted the signaling response of nicotine. The pesticides (at 3–30 µM) also blunted the response to the non-α7 agonist ABT 594 in LUHMES cells. These data show that human neuronal cells are functionally affected by low micromolar concentrations of several neonicotinoids. An effect of such signals on nervous system development is a toxicological concern.

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“…To evaluate OPP exposure, urinary concentrations of common OPP metabolites, i.e., dialkylphosphates (DAPs) including dimethylphosphate (DMP), diethylphosphate (DEP), dimethylthiophosphate (DMTP), diethylthiophosphate (DETP), dimethylditiophosphate (DMDTP) and diethyldithiophosphate (DEDTP), are usually used as biomarkers in cohort studies [ 15 ]. OPPs with mono-thio or di-thio moieties have been reported to be metabolised by three kinds of DAPs, i.e., dialkyl, dialkylthio and dialkyidithio phosphates [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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Profiles of urinary neonicotinoids and dialkylphosphates in populations in nine countries

Cited by 64 publications

References 43 publications

Human Exposures to Neonicotinoids in Kumasi, Ghana

Human Exposures to Neonicotinoids in Kumasi, Ghana

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

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