Profiles of serum IGF-I concentrations in calves from birth to eighteen months of age and in cows throughout the lactation Cycle

Kerr, David E.; Manns, J. G.; Laarveld, B.; Fehr, Manuela

doi:10.4141/cjas91-085

Cited by 66 publications

(44 citation statements)

References 29 publications

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“…Yet, female calves had greater plasma concentrations of total protein, glucose, insulin and IGFBPs in the present study, but gender did not affect the growth performance and plasma IGF-I. These findings are surprising because growth rates and plasma IGF-I are typically greater in male than in female calves [36,85–87], but not all studies indicate differences in the growth rate or plasma IGF-I during the milk-fed period [88,89]. One explanation could be that in the present study, the birth weight was not affected by gender, but birth weight is strongly correlated with the subsequent body weight in calves [90].…”

Section: Discussioncontrasting

confidence: 56%

Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves

et al. 2016

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The pre-weaning period is critical for calf health and growth, and intensive milk feeding programs may assist postnatal development by improving body growth and organ maturation. The aim of the present work was to study the effects of ad libitum milk replacer (MR) feeding on the growth, metabolic adaptation, health, and immune status of newborn calves. Twenty-eight newborn Holstein and Holstein x Charolais crossbred calves were fed ad libitum (ADLIB) or in restricted amounts (6 liters per day; RES) during the first five weeks of life. The MR intake in the ADLIB treatment was gradually reduced at weeks 6 and 7, and all calves then received 6 liters of MR per day until day 60. Blood samples were collected to measure the plasma concentrations of metabolites, insulin, insulin-like growth factor (IGF)-I and IGF binding proteins (IGFBP), immunoglobulins, and acute phase proteins. The expression of mRNA associated with both the somatotropic axis and gluconeogenic enzymes was measured in the liver on day 60. Intensive feeding improved MR intake and growth in ADLIB without influencing concentrate intake. Carcass weight, perirenal fat, and muscle mass were greater in ADLIB. Plasma concentrations of glucose, triglycerides, insulin, and IGF-I were greater, whereas plasma concentrations of β-hydroxybutyrate, total protein, albumin, urea, IGFBP-2 and -4, and fibrinogen were lower at distinct time points in ADLIB. The hepatic mRNA expression of cytosolic phosphoenolpyruvate carboxykinase was greater in ADLIB. Most metabolic and endocrine differences occurred during the MR feeding period, but a slightly greater concentrate intake was associated with increased plasma IGF-I and insulin at the end of the study. The immune and health status of the calves were not affected by MR feeding. However, increased plasma fibrinogen in the RES group suggested differences in the acute phase response.

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Section: Discussioncontrasting

confidence: 56%

Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves

et al. 2016

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“…In both early and traditionally weaned calves, ADG, IGF-I, and leptin concentrations increased from 150 d until slaughter, but no significant relationship was detected among these variables. Although IGF-I concentrations were indicative of growth potential at some points in the production cycle, it was not a suitable predictor for ADG in the long term (see also Kerr et al, 1991;Connor et al, 2000).…”

Section: Serum Igf-i and Leptin Concentrationsmentioning

confidence: 97%

Effects of early weaning and breed on calf performance and carcass and meat quality in autumn-born bull calves

et al. 2009

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“…Therefore, effects of glucocorticoids on IGF-I plasma concentrations are variable and may depend on treatment-dose (34) and age (9). In any case, plasma IGF-I concentrations increase during postnatal development in cattle (7,28,44). Therefore, elevated IGF-I concentrations in Dexa-treated calves, lower GH-to-IGF-I ratios in Dexa-treated calves, and the trend of lower GH-to-IGF-I ratios in colostrum-fed than in formula-fed calves indicate enhanced maturation of the somatotropic axis, as defined by Gluckman et al (19).…”

Section: Discussionmentioning

confidence: 99%

Effects of dexamethasone and colostrum intake on the somatotropic axis in neonatal calves

Sauter¹,

Ontsouka²,

Roffler³

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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Glucocorticoids and colostrum feeding influence postnatal maturation of the somatotropic axis. We have tested the hypothesis that dexamethasone (Dexa) affects the somatotropic axis in neonatal calves dependent on colostrum intake. Calves were fed either with colostrum or with a milk-based formula ( n = 14/group), and, in each feeding group, one-half of the calves were treated with Dexa (30 μg · kg body wt-1 · day-1). Pre- and postprandial blood samples were taken on days 1, 2, 4, and 5, and liver samples were taken on day 5 of life. Dexa increased insulin-like growth factor (IGF)-I, but decreased growth hormone (GH) and IGF-binding protein (IGFBP)-1 and -2 plasma concentrations and increased GH receptor (GHR) mRNA levels in liver. Dexa increased IGF-I mRNA levels only in formula-fed calves and increased hepatic GHR binding capacity, but only in colostrum-fed calves. Colostrum feeding decreased IGFBP-1 and -2 plasma concentrations and hepatic IGFBP-2 and -3 mRNA levels. In conclusion, Dexa and colostrum feeding promoted maturation of the somatotropic axis. Dexa effects partly depended on whether colostrum was fed or not.

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Profiles of serum IGF-I concentrations in calves from birth to eighteen months of age and in cows throughout the lactation Cycle

Cited by 66 publications

References 29 publications

Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves

Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves

Effects of early weaning and breed on calf performance and carcass and meat quality in autumn-born bull calves

Effects of dexamethasone and colostrum intake on the somatotropic axis in neonatal calves

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