Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease

Irish, Muireann; Hornberger, Michael; Lah, Sunčica; Miller, Laurie A.; Pengas, George; Nestor, Peter J.; Hodges, John R.; Piguet, Olivier

doi:10.1016/j.neuropsychologia.2011.05.017

Cited by 202 publications

(211 citation statements)

References 64 publications

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“…In particular, the retrieval of self-related information in AD patients lacks contextual details. The results are also congruent with previous studies that have revealed that the retrieval of autobiographical memories in AD patients is deprived of contextual details (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011;Piolino et al, 2003;Martinelli et al, 2013), suggesting that high-order self-related processes are impaired in AD patients.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 91%

“…In the same line, the quality of the recollective experience for autobiographical memories is impaired in AD patients (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011;Piolino et al, 2003). In particular, AD patients are impaired across a range of behavioural characteristics inherent to recollective experience, such as self-referential imagery, vividness and retrieval of contextual details (Irish, Hornberger, et al, 2011;Irish, Lawlor, et al, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 96%

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Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Genon

Bahri

Collette

et al. 2014

Cortex

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In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer's disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for selfrelevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience).The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of selfrelated information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for selfrelated information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC.

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 91%

Section: Accepted Manuscriptmentioning

confidence: 96%

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Genon

Bahri

Collette

et al. 2014

Cortex

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“…This finding suggests that even when AD patients have controlled episodic retrieval abilities, the complex retrieval of spontaneous associations may be impaired and successfully retrieved memories may lack contextual details. This assumption is congruent with previous findings that the recall of AD patients is characterised by poor contextual details even when probes are provided to encourage greater recall of details (Irish et al, 2011a(Irish et al, , 2011b.…”

Section: Functional Connectivity During Associative Cersupporting

confidence: 91%

“…In the same vein, Irish et al have recently examined the quality of the recollective experience for retrograde memories in AD patients (Irish et al, 2011a(Irish et al, , 2011b. They reported that AD patients were impaired across a range of behavioural markers inherent in the recollective experience such as self-referential imagery, vividness and retrieval of contextual details.…”

Section: Introductionmentioning

confidence: 99%

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

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Typical Alzheimer's disease (AD) is characterized by an impaired form of associative memory, recollection, that includes the controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD-), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). When performing group comparisons, no region was found to be significantly more activated during CER in HC than AD+ and vice versa. However, during associative CER, functional connectivity between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification.

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“…It has been proved that for AD patients, semantic, autobiographical and implicit memory are more preserved than recent memory; therefore our work is based on the subjects' autobiographical memory [12,13,15]. Thus a novel dataset was created based on these symptoms providing RGB, IR and Depth video data of the participants' faces, EEG and eye-gaze data.…”

Section: Introductionmentioning

confidence: 99%

Emotion Understanding Using Multimodal Information Based on Autobiographical Memories for Alzheimer’s Patients

Montenegro¹,

Gkelias

Argyriou³

2017

Computer Vision – ACCV 2016 Workshops

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Abstract. Alzheimer Disease (AD) early detection is considered of high importance for improving the quality of life of patients and their families. Amongst all the different approaches for AD detection, significant work has been focused on emotion analysis through facial expressions, body language or speech. Many studies also use the electroencephalogram in order to capture emotions that patients cannot physically express. Our work introduces an emotion recognition approach using facial expression and EEG signal analysis. A novel dataset was created specifically to remark the autobiographical memory deficits of AD patients. This work uses novel EEG features based on quaternions, facial landmarks and the combination of them. Their performance was evaluated in a comparative study with a state of the art methods that demonstrates the proposed approach.

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Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease

Cited by 202 publications

References 64 publications

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Emotion Understanding Using Multimodal Information Based on Autobiographical Memories for Alzheimer’s Patients

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