Profile of tirzepatide in the management of type 2 diabetes mellitus: design, development, and place in therapy

Naseralallah, Lina; AbouJabal, Bodoor

doi:10.1080/14656566.2023.2181074

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…These medications, which operate through diverse mechanisms, demonstrate favorable hypoglycemic effects and offer potential benefits in preserving or even safeguarding pancreas function. Among these, SGLT-2i, GLP-1RA, dual glucose-dependent diabetes peptides (GIP), and the GLP-1RA tirzepatide exhibit a range of additional advantages beyond glucose reduction, including potential mechanisms for remission of T2DM, such as weight loss ( 71 , 103 – 105 ). Hence, there exist numerous unexplored and enhanced areas within the domain of diabetes remission research that warrant future investigation.…”

Section: Discussionmentioning

confidence: 99%

Global research trends of diabetes remission: a bibliometric study

Yang,

He,

Chen

et al. 2023

Front. Endocrinol.

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BackgroundResearch on diabetes remission has garnered prominence in recent years. However, to date, no pertinent bibliometric study has been published. This study sought to elucidate the current landscape and pinpoint potential new research directions through a bibliometric analysis of diabetes remission.MethodsWe perused relevant articles on diabetes remission from January 1, 2000, to April 16, 2023, in the Web of Science. We utilized CiteSpace software and VOSviewer software to construct knowledge maps and undertake analysis of countries, institutional affiliations, author contributions, journals, and keywords. This analysis facilitated the identification of current research foci and forecasting future trends.ResultsA total of 970 English articles were procured, and the annual publication volume manifested a steady growth trend. Most of the articles originated from America (n=342, 35.26%), succeeded by China and England. Pertaining to institutions, the University of Newcastle in England proliferated the most articles (n=36, 3.71%). Taylor R authored the most articles (n=35, 3.61%), and his articles were also the most co-cited (n=1756 times). Obesity Surgery dominated in terms of published articles (n=81, 8.35%). “Bariatric surgery” was the most prevalently used keyword. The keyword-clustering map revealed that the research predominantly centered on diabetes remission, type 1 diabetes, bariatric surgery, and lifestyle interventions. The keyword emergence and keyword time-zone maps depicted hotspots and shifts in the domain of diabetes remission. Initially, the hotspots were primarily fundamental experiments probing the feasibilities and mechanisms of diabetes remission, such as transplantation. Over the course, the research trajectory transitioned from basic to clinical concerning diabetes remission through bariatric surgery, lifestyle interventions, and alternative strategies.ConclusionOver the preceding 20 years, the domain of diabetes remission has flourished globally. Bariatric surgery and lifestyle interventions bestow unique advantages for diabetes remission. Via the maps, the developmental milieu, research foci, and avant-garde trends in this domain are cogently portrayed, offering guidance for scholars.

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Section: Discussionmentioning

confidence: 99%

Global research trends of diabetes remission: a bibliometric study

Yang,

He,

Chen

et al. 2023

Front. Endocrinol.

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Current Therapeutical Approaches Targeting Lipid Metabolism in NAFLD

Vitulo

Gnodi

Rosini

et al. 2023

IJMS

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Nonalcoholic fatty liver disease (NAFLD, including nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH)) is a high-prevalence disorder, affecting about 1 billion people, which can evolve to more severe conditions like cirrhosis or hepatocellular carcinoma. NAFLD is often concomitant with conditions of the metabolic syndrome, such as central obesity and insulin-resistance, but a specific drug able to revert NAFL and prevent its evolution towards NASH is still lacking. With the liver being a key organ in metabolic processes, the potential therapeutic strategies are many, and range from directly targeting the lipid metabolism to the prevention of tissue inflammation. However, side effects have been reported for the drugs tested up to now. In this review, different approaches to the treatment of NAFLD are presented, including newer therapies and ongoing clinical trials. Particular focus is placed on the reverse cholesterol transport system and on the agonists for nuclear factors like PPAR and FXR, but also drugs initially developed for other conditions such as incretins and thyromimetics along with validated natural compounds that have anti-inflammatory potential. This work provides an overview of the different therapeutic strategies currently being tested for NAFLD, other than, or along with, the recommendation of weight loss.

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Profile of tirzepatide in the management of type 2 diabetes mellitus: design, development, and place in therapy

Cited by 2 publications

References 57 publications

Global research trends of diabetes remission: a bibliometric study

Global research trends of diabetes remission: a bibliometric study

Current Therapeutical Approaches Targeting Lipid Metabolism in NAFLD

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