Profile of systemic sclerosis and associated renal involvement

Shanavas, Neehar; Das, Anup Kumar

doi:10.4103/2321-4848.171908

Cited by 2 publications

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“…In SSc one of the most significant, acute consequences of vasospasm and arterial damage is renal involvement. In contrast to pulmonary arterial hypertension, which is characterized by slowly progressive vasculopathy, the vascular changes in renal scleroderma usually develop rapidly due to higher values of systemic blood pressure in comparison to pulmonary pressure [4]. The renal involvement in SSc may remain subclinical until the late stages [5].…”

Section: Introductionmentioning

confidence: 99%

Renal Involvement in Systemic Sclerosis: An Update

Chrabąszcz

Małyszko

Sikora

et al. 2020

Kidney Blood Press Res

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Background: Systemic sclerosis is an immune-mediated rheumatic disease characterized by vascular abnormalities, tissue fibrosis and autoimmune phenomena. Summary: Renal disease occurring in patients with systemic sclerosis may have a variable clinicopathological picture. The most specific renal condition associated with systemic sclerosis is scleroderma renal crisis, characterized by acute onset of renal failure and severe hypertension. Although the management of scleroderma renal crisis was revolutionized by the introduction of angiotensin-converting enzyme inhibitors, there is still a significant proportion of patients with poor outcomes. Therefore, research on establishing disease markers (clinical, ultrasonographical and serological) and clear diagnostic criteria, which could limit the risk of developing scleroderma renal crisis and facilitate diagnosis of this complication, is ongoing. Other forms of renal involvement in systemic sclerosis include vasculitis, an isolated reduced glomerular filtration rate in systemic sclerosis, antiphospholipid-associated nephropathy, high intrarenal arterial stiffness and proteinuria. Key Messages: Scleroderma renal crisis is the most specific and lifethreatening renal presentation of systemic sclerosis, albeit with declining prevalence. In patients with scleroderma renal crisis, it is mandatory to control blood pressure early with increasing doses of angiotensin-converting enzyme inhibitors, along with other antihypertensive drugs if necessary. There is a strong association between renal involvement and patients' outcomes in systemic sclerosis; consequently, it becomes mandatory to find markers that may be used to identify patients with an especially high risk of scleroderma renal crisis.

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Section: Introductionmentioning

confidence: 99%

Renal Involvement in Systemic Sclerosis: An Update

Chrabąszcz

Małyszko

Sikora

et al. 2020

Kidney Blood Press Res

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Systemic Scleroderma—Definition, Clinical Picture and Laboratory Diagnostics

Kowalska-Kępczyńska

2022

JCM

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(1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an autoimmune disorder. The pathogenesis of this disease is not fully understood. (2) Methods: This article reviews the literature on systemic scleroderma (SSc). A review of available scientific articles was conducted using the PubMed database with a time range of January 1985 to December 2021. (3) Results and Conclusions: The article is a review of information on epidemiology, criteria for diagnosis, pathogenesis, a variety of clinical pictures and the possibility of laboratory diagnostic in the diagnosis and monitoring of systemic scleroderma.

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Profile of systemic sclerosis and associated renal involvement

Cited by 2 publications

References 0 publications

Renal Involvement in Systemic Sclerosis: An Update

Renal Involvement in Systemic Sclerosis: An Update

Systemic Scleroderma—Definition, Clinical Picture and Laboratory Diagnostics

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