Profile of sinonasal malignant tumor patients in Adam Malik General Hospital Medan-Indonesia

Fadly, Fiza; Farhat, Farhat; Asnir, Rizalina Arwinati

doi:10.15562/bmj.v7i1.810

Cited by 2 publications

(4 citation statements)

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“…However, Franchi et al, (27) results werein disagreement with results our where they found sinonasal undifferentiated carcinoma occurring in male more than females. Alsoin US, Turner and Reh et al, (28) , found sinonasal malignant tumors were in higher incidence in male patients (58.3%) and in Iran, Poursadegh, (29) found 1.8 times males more frequent than females.Similar results of higher male-to-female ratios for malignant sinonasal tumors were reported by Kawaguchi et al, (30) , Fadly et al, (25) and Arti et al, (23) . However, a fairly accepted explanation is the higher carcinogenic exposure of males (31) .In contrast to the present study, Bakari et al, in (32) found a higher preponderance of females than males in sinonasal papillomas where could be related to the sample size of patients enrolled in these studies.…”

Section: Discussionsupporting

confidence: 87%

“…The study by Shirazi et al, (24) showed that the advanced stratum age (40-50) in sinonasal and nasopharyngeal was most affected. Fadly et al, (25) found that the highest incidence (27.7%) of the sinonasal malignant tumors was in those 41-50 years. This could be explained by the impairment and/ or decline in the immune system in those old ages.…”

Section: Discussionmentioning

confidence: 97%

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Molecular Detection of Kaposi’s Sarcoma Associated Virus (Human Herpes Virus 8) in Sino-Nasal Carcinoma Tissues

Shaker¹,

Yasir²,

Alajeely³

et al. 2020

ATMPH

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Sinonasal malignant neoplasms are rare and heterogeneous tumors of sinonasal tract, constituting about 3% of the upper respiratory tract tumors. A variety of gene products encoded by Human herpes Virus -8,are involved in transformation, as well as promotion of oncogenesis. angiogenesis, anti-apoptosis, and immune modulation and evasion. The aim is to unravel the ratesof Human herpes Virus -8 (HHV-8) infections in tissues from a group of patients with sinonasal carcinoma (SNC) and sinonasal papilloma (SNP). Eighty-three formalin-fixed, paraffin-embedded sinonasal carcinoma (SNC) and sinonasal papilloma (SNP)tissues enrolled in this study; 18 sinonasal tissue biopsies from sinonasal carcinoma; 35 tissue biopsies from sinonasal papilloma and 30 apparently healthy nasopharyngeal tissues with unremarkable pathological changes, as control group. Detection of HHV-8 was done by new detection version of chromogenic in situ hybridization (CISH) technique. The positive CISH reactions for HHV-8-DNA were detected in 22.2% and 5.7% of sinonasal carcinoma and sinonasal papilloma tissues, respectively. And no control tissues presented positive signals for HHV-8-CISH test. The correlation between HHV-8 and sinonasal carcinoma and sinonasal papilloma was highly significant (P= 0.001). The significant HHV-8 detection rates in sinonasal carcinoma and sinonasal papilloma tissues might shade light for a possible role of this virus in either sinonasal pathogenesis or carcinogenesis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 97%

Molecular Detection of Kaposi’s Sarcoma Associated Virus (Human Herpes Virus 8) in Sino-Nasal Carcinoma Tissues

Shaker¹,

Yasir²,

Alajeely³

et al. 2020

ATMPH

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“…Of 71 malignant tumors found in this study, the most histopathological type was nonkeratinizing squamous cell carcinoma in 41 patients (43.2%). The same thing is also found in research conducted by Fadly et al, [16] Sinonasal tumor patients generally receive therapy in the form of surgery, as many as 28 patients (29.5%). In addition, some patients also receive therapy adjuvant in the form of chemotherapy and radiation, or a combination of the two after surgery.…”

Section: Discussionsupporting

confidence: 76%

“…While sinonasal malignancies are rare cases with an incidence rate of around 0.55 cases per 100,000 population per year [5]. The highest incidence of sinonasal malignancy is found in Japan, which is 2 cases per 10,000 population per year [6]. In Europe, in 2003 around 14,500 people were diagnosed with epithelial tumors originating from the nasal cavity [7].…”

Section: Introductionmentioning

confidence: 99%

Profile of Sinonasal Tumor Patient in Adam Malik General Hospital 2016-2018

et al. 2020

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Abstract. Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely found, only <3% of all malignancy in head and neck, and 1% of all malignancy in the body. Although it is rarely found, it can cause serious complication in adult. Unspecific sign and symptoms of sinonasal tumor often make the patients ignore the disease. It leads to the diagnosis of this disease becomes late and the patients come to the doctor in advanced stage. This research was conducted to know about the profile of sinonasal tumor patients in H. Adam Malik Medan Hospital on 2016-2018. The study was a descriptive study with retrospective approach. The data used are secondary data taken from medical records. The data were analyzed using a statistical application programs. Sinonasal tumor patients in RSUP HAM Medan are 158 patients, where 95 patients met the inclusion criteria, consisting of 24 benign tumors (25,3%) and 71 malignant tumors (74,7%). The majority of patients are male (71,6%), and the highest age group in in 51-60 years old (31,6%). The main complaints felt by the patients were nasal symptoms (64,2%), the location of tumors mostly found in nasal cavity (50,5%), the most histopathological type is NKSCC (43,2%), the most occupation is self-employment (26%), and the treatment of the patients are surgery (29,5%). Keyword: Sinonasal Tumor, Profile, Sinonasal Cancer

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Profile of sinonasal malignant tumor patients in Adam Malik General Hospital Medan-Indonesia

Cited by 2 publications

References 0 publications

Molecular Detection of Kaposi’s Sarcoma Associated Virus (Human Herpes Virus 8) in Sino-Nasal Carcinoma Tissues

Molecular Detection of Kaposi’s Sarcoma Associated Virus (Human Herpes Virus 8) in Sino-Nasal Carcinoma Tissues

Profile of Sinonasal Tumor Patient in Adam Malik General Hospital 2016-2018

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