Profile of major congenital anomalies in the Dhahira region, Oman

Patel, Prakash

doi:10.5144/0256-4947.2007.106

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…Frequency of consanguineous marriages was higher among parents of offspring with congenital malformations compared with the figures for the general population in all studies reported among Arabs, including in the UAE [ 28 , 35 - 37 ], Kuwait [ 29 ], Oman [ 30 , 38 , 39 ], Iraq [ 40 , 41 ], Jordan [ 42 , 43 ], Egypt [ 44 ], Lebanon [ 4 , 45 ], Tunisia [ 46 ], Arabs in Jerusalem [ 33 ], and Saudi Arabia [ 47 ]. After controlling for confounders, first cousin consanguinity remained significantly associated with an increased risk of congenital heart defects (CHD), where infants born to consanguineous parents had a higher risk of having a CHD diagnosed at birth compared to those born to unrelated parents in Lebanon [ 48 , 49 ], Saudi Arabia [ 47 , 50 , 51 ], Egypt [ 52 ], and Arabs in Israel [ 53 ].…”

Section: Negative Effects Of Consanguinity On Reproductive Healthmentioning

confidence: 86%

Consanguinity and reproductive health among Arabs

et al. 2009

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Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity.

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Section: Negative Effects Of Consanguinity On Reproductive Healthmentioning

confidence: 86%

Consanguinity and reproductive health among Arabs

et al. 2009

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“…In Middle Eastern countries, the prevalence of consanguinity is known to be high. Besides that, important association between consanguinity among couples and increased rate of congenital anomalies has been reported in previous studies (23,(29)(30)(31)(32)(33). In our study sample, 22% of mothers were married to their first cousins.…”

Section: Discussionmentioning

confidence: 81%

Major Congenital Anomalies: A New Rising Tide of Concern to the Health System

Salmi¹,

Salmani²,

Fahdi³

et al. 2020

Preprint

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“…Usually occurs after 36 th week of gestation in gestational diabetes. 36,37 Causes are chronic intrauterine hypoxia with acidosis, high fasting blood sugar levels, placental dysfunction and competition for essential nutrients. 38,39 Women with gestational diabetes are in high-risk category for foetal death.…”

Section: Intrauterine Death/ Still Birthmentioning

confidence: 99%

Perinatal outcome in relation to maternal glycaemic control in gestational diabetes mellitus

Kanmani¹,

Subramanian²

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Early diagnosis and treatment of gestational diabetes with adequate antenatal care are essential to reduce the adverse neonatal outcomes.Methods: All selected women were subjected to a detailed history taking comprising of age, parity, prepregnant body weight, medication history, family history, medical history, detailed obstetric history. Then they were subjected to clinical examination and routine laboratory investigations. Antenatal women were diagnosed with GDM, when 75gm GCT ≥140mg/dl based on DIPSI criteria. Fasting and postprandial blood sugars (2hours) were done and if FBS and PPBS were normal, the patient was labelled as GDM on meal plan. If fasting > 96 mg/dl and 2-hr postprandial blood sugar >121 mg/dl, Inj.insulin was started. Patients were managed according to the FBS and PPBS values throughout antenatal period and the perinatal outcomes were studied.Results: Among 150 patients, multiparous women constitute 65.3% and primi 34.7%. 60% of the patients were in age group of 26 to 30 years.59.3% of patients were in BMI of range 25 to 30.Family history of diabetes was present in 24.7% of the patients. Previous history of GDM was present in 27.3% of cases.98% of GDM were detected in 2nd trimester. The percentage of cases presented with macrosomia was 8.7%, RDS 3.3%, hypoglycaemia 6%, hyperbilirubinemia 3.3%, IUD 0.7%, perinatal injury 1.3%, NICU admission requiring ≥3 days of admission was 12%.Conclusions: There is association of elevated FBS and PPBS values with occurrence of adverse perinatal outcome.

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Profile of major congenital anomalies in the Dhahira region, Oman

Cited by 12 publications

References 17 publications

Consanguinity and reproductive health among Arabs

Consanguinity and reproductive health among Arabs

Major Congenital Anomalies: A New Rising Tide of Concern to the Health System

Perinatal outcome in relation to maternal glycaemic control in gestational diabetes mellitus

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