Profile of lower urinary tract symptoms in the male and their impact on quality of life

Healthcare resource utilization and cost among males with lower urinary tract symptoms with a predominant storage component in Spain: The epidemiological, cross‐sectional MERCURY study

“…4 Another study (EpiLUTS) determined the prevalence of at least one LUTS occurring "sometimes" or more to be 72.3%, and occurring "often" or more to be 47.9% in the general population in the US, UK, and Sweden. 19 In a previous report of Spanish adult males with LUTS, 69% of patients reported the overlap of storage, voiding, and post-micturition symptoms, 5 which is consistent with findings of LUTS overlap in the patient population of the current study. The rates of bother in the EpiLUTS study were greatest for those who reported multiple storage, voiding and post-micturition LUTS, and were associated with decreased HRQoL.…”

“…The most common LUTS were nocturia, frequency, and urgency, which also had the greatest impact on HRQoL . Another epidemiological study of 826 adult males with LUTS attending urology clinics in Spain reported an overlap of storage, voiding, and post‐micturition symptoms in 69% of patients and found that storage symptoms were responsible for medical consultation in 86% of patients …”

“…4 Another epidemiological study of 826 adult males with LUTS attending urology clinics in Spain reported an overlap of storage, voiding, and post-micturition symptoms in 69% of patients and found that storage symptoms were responsible for medical consultation in 86% of patients. 5 The cost associated with LUTS has been reported to be substantial and is expected to increase to over €5 billion annually by the year 2020 in European countries. 6 The Trans European Research into the use of Management Policies for LUTS suggestive of BPH in Primary Healthcare (TRIUMPH) study showed that the annual cost per patient varied among six European countries, ranging from €292 to €1337.…”

A retrospective analysis comparing persistence and adherence to treatment with free‐ vs fixed‐dose combination of an alpha blocker and an antimuscarinic agent in men with LUTS in Spain

“…Despite the negative impact of LUTS on patients’ QoL and the evidence that available treatments are effective, many patients with mixed storage and voiding symptoms may not be receiving optimal care 3‐6,8‐10 . Firstly, the use of add‐on therapy with an OAB drug (eg, an AM) to target unresolved storage symptoms in patients treated with an AB remains low and, secondly, even in those patients receiving appropriate combination treatment, drug adherence and persistence can be poor 11‐14 .…”

“…Notably, approximately 50% of men experience “mixed” LUTS with both a voiding component (often attributed to benign prostatic obstruction [BPO] because of benign prostatic hyperplasia [BPH]) and a storage component (often attributed to overactive bladder [OAB]) 3 . The storage component is generally considered to be the most bothersome and can negatively impact patients’ physical and mental health, and their quality of life (QoL) 3‐6 …”