Profile of Leukocytes Amount in Various Levels of HbA1c in Diabetics Mellitus

Abstract

Blood glucose images in patients with diabetic mellitus (DM) can be assessed by measurements of glycated hemoglobin (HbA1c). HbA1c is formed because hyperglycemia forms a stable and settling bond. DM sufferers have increased proinflammatory cytokine production, such as interleukin 6 (IL-6) and interleukin 8 (IL-8) which will then spur the production of white blood cells. Leukocyte count plays an important role in the pathogenesis of insulin resistance and is one of the indicators of inflammation. The purpose of this study was to find out the profile of leukocytes at various levels of HbA1c with diabetic mellitus. The method of this research is an analytic observational with a cross-sectional approach. Data was collected and analyzed using non-parametric statistics for Spearman Rank Test. The results of this study show that at the average Normal HbA1c level, 6.39%, the average number of leukocytes is normal, which is 7.018 μL, as well as the average level of HbA1c above normal, 9.26% the average number of leukocytes is normal 9,818 μL. Based on the statistical test results obtained the significance value of 0.317 (α > 0.05) with a correlation coefficient of 0.277. The conclusion of this study is an increase in the levels of HbA1c in patients with diabetic mellitus does not provide an overview of the increase in the number of leukocytes.