Profile of infective endocarditis observed from 2003 - 2010 in a single center in Italy

Ferraris, Laurenzia; Milazzo, Laura; Ricaboni, Davide; Mazzali, Cristina; Orlando, Giovanna; Rizzardini, Giuliano; Cicardi, Marco; Raimondi, Ferdinando; Tocalli, Loredana; Cialfi, Alessandro; Vanelli, Paolo; Galli, Massimo; Antona, Carlo; Antinori, Spinello

doi:10.1186/1471-2334-13-545

Cited by 29 publications

(29 citation statements)

References 33 publications

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“…There are coding issues and different practices among doctors and hospitals; a better standardization is needed. Merging the two data-bases allowed a quality control and greater accuracy; this may explain why the incidence rate was higher than previously reported by other prospective European studies (13,23). Hoen estimated an incidence of 3,1/100.000 per year but an under-reporting may have been due to the absence of an "active search" of cases by investigators (13).…”

Section: Discussioncontrasting

confidence: 39%

“…Streptococcus viridans and enterococcal IE were mainly communityacquired, whereas enterobacteriaceae/gram negative forms were nearly equally distributed between community and nosocomial origin. Incidence of staphylococcus aureus IE did not increase in the study period, P=0.95, not confirming previous studies results (10,22,23). Culture negative IE's were 11%, a lower prevalence than recently reported in European countries (24,25).…”

Section: Microbiologysupporting

confidence: 30%

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Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study

Cresti¹,

Chiavarelli²,

Scalese³

et al. 2017

Cardiovasc. Diagn. Ther.

197

175

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Background: The population at risk, the clinical and microbiological features of infective endocarditis (IE) have changed. Aim of our study was to evaluate the contemporary epidemiological trends, over a 17-year period in a definite region of Tuscany, Italy, to analyze the clinical outcomes and associated prognostic factors.Methods: From 1 January 1998 to 31 December 2014, all patients with a definite diagnosis of IE were prospectively entered in a data-base. The Health-Care system data-base was interrogated to capture patients who could have been missed. The final dataset derived by the merging of the two data-bases.Results: Incidence rate of IE was 4.6/100,000/y with a significant linear incidence increase. In hospitalized patients the incidence was 1.27/1,000 admissions. Over age 65 incidence rate was 11.7/100,000/y.Male/female ratio was 1.54:1. A temporal trend towards an increase in the mean population age was found (P=0.033). There was an increase in the incidence of Health-care associated IE, P=0.016. The most common microorganisms were staphylococcus aureus (25%) and coagulase-negative staphylococci (22%).In-hospital mortality was 24%. A trend towards an increase in mortality rate was found (P=0.055).Independent predictors of mortality were older age, S. aureus infection, heart failure, septic shock and persistent bacteremia. Conclusions:Our study confirms an increasing mortality trend in IE, although with a borderline significance. Elderly forms are associated with poor prognosis and higher than 1-year mortality rate even in the multivariate analysis. Ageing population, increase in healthcare-associated and staphylococcal infections, may explain the rise of IE incidence and of the mortality trend.

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Section: Discussioncontrasting

confidence: 39%

Section: Microbiologysupporting

confidence: 30%

Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study

Cresti¹,

Chiavarelli²,

Scalese³

et al. 2017

Cardiovasc. Diagn. Ther.

197

175

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“…Rozpoczynająca się dysfunkcja nerek niezależnie wiąże się ze zwiększonym ryzykiem zgonu wewnątrzszpitalnego [291,292] i incydentów pooperacyjnych [293].…”

Section: Ostra Niewydolność Nerekunclassified

“…Ostra niewydolność nerek występuje u ok. 6-30% pacjentów [291,292,294,295]. Etiologia często jest wieloczynnikowa [296,297]: (i) kompleksy immunologiczne i naczyniowe kłębuszkowe zapalenie nerek; (ii) zawał nerki, głównie na skutek zatorów septycznych, występujący w dowolnym czasie w przebiegu IZW; (iii) pogorszenie funkcji hemodynamicznych w przypadku HF lub ciężkiej posocznicy albo w okresie pooperacyjnym; (iv) nefrotoksyczność antybiotyków (ostre śródmiąższowe zapalenie nerek), wyraźnie związane ze stosowaniem aminoglikozydów, wankomycyny (toksyczne działanie synergistyczne z aminoglikozydami), a nawet benzylopenicyliny w wysokich dawkach; (v) nefrotoksyczność środków kontrastowych stosowanych w diagnostyce obrazowej.…”

Section: Ostra Niewydolność Nerekunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

212

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“…[1][2][3] IE also frequently causes debilitating morbidities, such as heart failure, stroke and renal failure requiring dialysis, which contribute to increased mortality and disability adjusted life years (DALYs). [3][4][5][6][7] The spectrum of causative microorganisms and underlying risk factors for IE has shifted dramatically in high income countries (HICs). 8,9 Staphylococcal IE now predominates.…”

Section: Infective Endocarditis In Low-and Middle-income Countries Inmentioning

confidence: 99%

Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

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Key Points Staphylococcus is an increasingly important cause of IE in LMICs, and is the leading cause of IE in UMICs  RHD remains the major underlying cardiac pathology of IE in LMICs, identified in almost half of reported cases  The rate of microorganism non-identification is high, reaching up to 60% of IE cases in LMICs, and hampering diagnosis and treatment  Rates of access to surgery in UMICs for complicated IE are as high as in HICs, but remain dismal in lower-middle income countries SynopsisInfective endocarditis (IE) is a rare, life-threatening disease with a mortality rate of upto 25% and significant debilitating morbidities. Although much has been reported on contemporary IE in high income countries, conclusions on the state of IE in low and middle income countries (LMICs) are based on studies conducted before the year 2000. Furthermore, unique challenges in the diagnosis and management of IE persist in LMICs. This article is a review of IE studies conducted in LMICs documenting clinical experiences from the year 2000 to present. We present the causes of IE, management of patients with IE and the prevailing challenges in diagnosis and treatment of IE in LMICs.

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Profile of infective endocarditis observed from 2003 - 2010 in a single center in Italy

Cited by 29 publications

References 33 publications

Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study

Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study

2015 ESC Guidelines for the management of infective endocarditis

Infective Endocarditis in Low- and Middle-Income Countries

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