Profile of HIV infected children: A hospital based study at Eastern Nepal

Poudel, Prakash; Pokharel, Rita; Chitlangia, Mohit; Chaudhary, Shipra

doi:10.1016/s2222-1808(14)60499-0

Cited by 13 publications

(26 citation statements)

References 15 publications

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“…Presenting features of children with HIV infection in our study are almost similar and comparable to the findings of other studies [Merchant et al, 2001;Gomber et al, 2011;Poudel et al, 2014]. The majority of patients were presented with weight loss, prolonged fever, hepatomegaly, splenomegaly, respiratory infection, and chronic diarrhea.…”

Section: Discussionsupporting

confidence: 90%

“…Although, high prevalence of tuberculosis was found in Zimbabwe (59%) and Bangladesh (23%) [Madani et al, 2004;Ferrand et al, 2007], we found lower frequency of this disease; it might be due to lower age of our population study. In this study similar to Poudel et al study, salmonella infections as well as streptococcal pneumonia and candida infections followed by tuberculosis and Pseudomonas aeruginosa infections were the predominant opportunistic infection [Poudel et al, 2014].…”

Section: Discussionsupporting

confidence: 86%

“…Although the majority of HIV children in other studies were in the WHO clinical stage 1 [Gomber et al, ; Poudel et al, ], in our study all the patients were in stage 3. In 97% of patients (N = 31), parental HIV diagnosis was recognized after HIV detection in their children.…”

Section: Discussioncontrasting

confidence: 66%

“…At the end of 2010, it had been reported that nearly one tenth (3.4 million) of people who were living with HIV were children less than 15 years [Poudel et al, 2014]. Asia is the second most HIVaffected region of the world [Craig et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of children with acquired immune deficiency syndrome (stage 3): A referral hospital‐based study in Iran

Movahedi

Mahmoudi

Pourakbari

et al. 2015

Journal of Medical Virology

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Lack of recognition of human immunodeficiency virus (HIV) infection especially in children and delayed implementation of effective control programs makes HIV infection as a major cause for concern. Information on HIV epidemiology in Iran as well as other Islamic countries is limited. The aim of our study was to describe the clinical manifestation and laboratory finding of HIV infected children who were admitted to a referral Children Medical Center (CMC) in Tehran, Iran, during 11 years from January 2002 to January 2013. This was a retrospective study carried out over a period of 11 years. The records of all patients attending to the CMC with confirmed acquired immunodeficiency syndrome (AIDS) were screened. The patients were evaluated for social circumstance, family history, age, gender, clinical, and laboratory features. Clinical data including fever, respiratory distress, diarrhea, rash, etc. as well as laboratory tests including complete blood count, serum glucose level, electrolytes, liver function test, cultures, CD4 lymphocyte count were evaluated. During the study period, 32 HIV positive children were enrolled. The majority of patients were presented with weight loss, prolonged fever, respiratory infection and chronic diarrhea. In this study, salmonella infections as well as streptococcal pneumonia and candida infections followed by, tuberculosis and Pseudomonas aeruginosa infections were the predominant opportunistic infections. Since the number of HIV-positive children has been alarmingly increasing in recent years and perinatal transmission is the most common route of HIV infection in children, essential recommendations for prenatal HIV testing as well as appropriate antiretroviral therapy by HIV infected mothers are needed.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of children with acquired immune deficiency syndrome (stage 3): A referral hospital‐based study in Iran

Movahedi

Mahmoudi

Pourakbari

et al. 2015

Journal of Medical Virology

View full text Add to dashboard Cite

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“…Majority i.e. 31.7% belonged to age group between 0-5 years, this also shares similarities with the other studies done in India and Nepal by Madhivan et al, Gomber et al and Poudel et al [9][10][11] The desired adherence level of >95% assessed by pill count was achieved in more than 90% of children in this study, similar results were seen in a study conducted by Anju S et al and Mehta K et al i.e. 95.3% and 90.9% respectively.…”

Section: Discussionsupporting

confidence: 90%

Adherence status of HIV infected children at ART centre of South India

Nayak

Prayag

2018

Int J Contemp Pediatr

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Background: Adherence to antiretroviral therapy (ART) is a principal determinant of virologic suppression. A variety of factors: including formulation of medicine, dose frequencing, drug toxicities, child’s age, as well as psychosocial, behavioral, and sociodemographic characteristics of children and caregivers have been associated with nonadherence. Still no consistent predictors of either good or poor adherence in children have been consistently identified.Methods: Data was collected from the ART Centre. Record based data from the year 2008 to 2018 April of pediatric age group i.e. from 0-18 years. All the cases registered at the center whose data were available were included for the study. Adherence was assessed calculating the average monthly consumption of ARV assessed by pill count as per NACO guidelines.Results: At the ART Centre, 139 (73.5%) were on treatment i.e. 75.7% of boys registered and 70.9% of registered girls. Average monthly adherence and treatment interruptions among the 73 children alive on ART, majority i.e. 90.4% were on good adherence with 8.2% on less than 80% adherence.Conclusions: Overall a good adherence indicates efficient functioning of the programme and determined efforts from the ART Centre.

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Investigation of the effects of a prevention of mother-to-child HIV transmission program among Iranian neonates

et al. 2018

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Human immunodeficiency virus (HIV) infection is mostly spreading in developing countries. One of the most important pathways of HIV infection in these nations is the vertical route, from mother to infant. Therefore, this study evaluated the effectiveness of the prevention of mother-to-child transmission (PMTCT) program for HIV among Iranian neonates born to HIV-positive mothers. A total of 54 neonates born to HIV-1 positive mothers, all of whom were in a PMTCT program for HIV, as per the Iranian guidelines, were enrolled in this descriptive cross sectional study from March 2014 to July 2017. After RNA extraction of a plasma specimen, HIV-1 viral load was tested by an Artus HIV-1 RG RT-PCR Kit. Out of 54 evaluated neonates, 32 (59.3%) were male. The mean age of the HIV-infected mothers was 30.1 ± 5.4 (range: 19-47) years, and 36 (66.7%) of the mothers were in the age group 26-34 years. In the present study, it was found that none of the neonates whose mothers had previously entered PMTCT programs had HIV. 15 children were found who were born to HIV-positive mothers who had not entered the PMTCT program. Three of these children were infected with HIV (CRF35_AD), and none of them carried HIV-1 variants with SDRMs. The results of this study indicate that if HIV-positive pregnant women enter the PMTCT program for HIV, they can realistically hope to give birth to a non-infected child.

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Profile of HIV infected children: A hospital based study at Eastern Nepal

Cited by 13 publications

References 15 publications

Epidemiology of children with acquired immune deficiency syndrome (stage 3): A referral hospital‐based study in Iran

Epidemiology of children with acquired immune deficiency syndrome (stage 3): A referral hospital‐based study in Iran

Adherence status of HIV infected children at ART centre of South India

Investigation of the effects of a prevention of mother-to-child HIV transmission program among Iranian neonates

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