Profile of Hashimoto's Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto's Thyroiditis?

Siriweera, E. H.; Ratnatunga, Neelakanthi

doi:10.4061/2010/124264

Cited by 30 publications

(20 citation statements)

References 20 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of coexisting of HT and DTC in thyroidectomy specimen ranges between 9.4 to 36%. [7][8][9] In our study, 47.4% of patients with DTC had associated HT. The mechanism behind this association is poorly understood.…”

Section: Discussionsupporting

confidence: 44%

Analyzing the relationship between differentiated thyroid cancer and thyroid autoimmunity: an exploratory study from tertiary care center in South India

et al. 2019

View full text Add to dashboard Cite

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. There is a rising incidence of DTC over the past few decades. This dramatic increase in incidence may be due to increased detection rate or because of factors like thyroid stimulating hormone (TSH) or thyroid autoantibodies which remains unclear. Our study aims to analyze the association between DTC and thyroid autoimmunity.Methods: This was a retrospective study over 1 year conducted at the department of endocrine surgery, Madras medical college, a tertiary care center in South India. During the study period, 364 total thyroidectomies were performed which includes 292 benign and 72 malignant cases. Among malignancies, 15 non-DTC cases were excluded from the study. Finally, we included 57 patients with DTC and 114 patients with benign disease (randomly chosen age and sex-matched controls) for analysis. Demographic data, TSH levels, antithyroglobulin (anti-TG), and anti-thyroid peroxidase (anti-TPO) antibody levels, histopathology were recorded and analyzed.Results: Histopathological examination revealed 47.4% of DTC and 63.2% of benign cases has associated thyroiditis. In our study elevated anti-TPO and anti-TG antibodies were not significantly associated with DTC (anti-TPO positivity 75.4% in DTC group vs. 74.6% in benign group, p=0.90, anti-TG antibody positivity 66.7% in DTC vs. 67.5% in benign group, p=0.90). Also, no significant association established between elevated TSH and DTC.Conclusions: Association between thyroid autoantibodies and DTC has been evaluated in several studies with inconsistent results. The present study did not show any significant associations between elevated thyroid autoantibodies, TSH levels, and DTC.

show abstract

Section: Discussionsupporting

confidence: 44%

Analyzing the relationship between differentiated thyroid cancer and thyroid autoimmunity: an exploratory study from tertiary care center in South India

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The sensitivity analyses revealed that no study had a significant influence on the overall estimates. The pooled ORs for HT varied from 2.04 (when excluding Siriweera et al [ 18 ]) to 2.24 (when excluding Matesa-Anic et al [ 23 ]). The shape of the funnel plot of studies assessing the association between HT and PTC risk seemed to be symmetrical, indicating the absence of publication bias (Figure 5 ).…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk

et al. 2017

View full text Add to dashboard Cite

ObjectiveIt remains inconclusive whether Hashimoto’s thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question.ResultsTwenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies. The mean rate of PTC among patients with HT ranged from 1.12% (selective FNA or thyroidectomy studies) to 40.11% (thyroidectomy studies). All three types of studies supported the correlation between HT and PTC. The overall pooled odds ratio (OR) of the PTC risk for HT (HT versus non-HT) was 2.12 (95% confidence interval [CI]: 1.78-2.52).MethodsWe searched all relevant published studies using the citation databases PubMed and Embase. The ORs and corresponding 95% CIs were calculated by the random-effects model for the association between HT and PTC.ConclusionsOur meta-analysis confirmed that HT predisposed patients to the development of PTC.

show abstract

“…Hashimoto’s thyroiditis (HT) is a frequent autoimmune thyroid disease, affecting approximately 5% of the general population, especially women [ 1 ]. HT is characterized by intrathyroidal monocyte infiltration along with rising serum autoantibodies, such as anti-thyroglobulin antibody (anti-Tg) and anti-thyroid peroxidase antibody (anti-TPO), and is the leading cause of hypothyroidism worldwide [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice

Cai

Wang

Chen

et al. 2018

J Neuroinflammation

View full text Add to dashboard Cite

BackgroundAlthough studies have reported an increased risk for mood disorders in Hashimoto’s thyroiditis (HT) patients even in the euthyroid state, the mechanisms involved remain unclear. Neuroinflammation may play a key role in the etiology of mood disorders in humans and behavioral disturbances in rodents. Therefore, this study established a euthyroid HT model in mice and investigated whether HT itself was capable of triggering neuroinflammation accompanied by emotional alterations.MethodsExperimental HT was induced by immunizing NOD mice with thyroglobulin and adjuvant twice. Four weeks after the last challenge, mice were tested for anxiety-like behavior in the open field and elevated plus maze tests and depression-like behavior in the forced swimming and tail suspension tests. Then, animals were sacrificed for thyroid-related parameter measure as well as detection of cellular and molecular events associated with neuroinflammation. The changes in components of central serotonin signaling were also investigated.ResultsHT mice showed intrathyroidal monocyte infiltration and rising serum thyroid autoantibody levels accompanied by normal thyroid function, which defines euthyroid HT in humans. These mice displayed more anxiety- and depressive-like behaviors than controls. HT mice further showed microglia and astrocyte activation in the frontal cortex detected by immunohistochemistry, real-time RT-PCR, and transmission electron microscopy (TEM). These observations were also accompanied by enhanced gene expression of proinflammatory cytokines IL-1β and TNF-α in the frontal cortex. Despite this inflammatory response, no signs of neuronal apoptosis were visible by the TUNEL staining and TEM in the frontal cortex of HT mice. Additionally, IDO1 and SERT, key serotonin-system-related genes activated by proinflammatory cytokines, were upregulated in HT mice, accompanied by reduced frontal cortex serotonin levels.ConclusionsOur results are the first to suggest that HT induces neuroinflammation and alters related serotonin signaling in the euthyroid state, which may underlie the deleterious effects of HT itself on emotional function.

show abstract

Profile of Hashimoto's Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto's Thyroiditis?

Cited by 30 publications

References 20 publications

Analyzing the relationship between differentiated thyroid cancer and thyroid autoimmunity: an exploratory study from tertiary care center in South India

Analyzing the relationship between differentiated thyroid cancer and thyroid autoimmunity: an exploratory study from tertiary care center in South India

A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk

Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice

Contact Info

Product

Resources

About