Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Abstract

Objective: Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas of the bladder. While the behavior of these superficial urothelial cancers is relatively benign, invasive tumors have a significant mortality rate. However, Ta and T1 tumors might display different biological behavior. There is therefore a great need for biomarkers that can accurately distinguish the behavior of urothelial carcinomas in addition to tumor grade and stage. our aim was to determine the immunohistochemical expression profile of insulin like growth factor ii mrna binding Protein 3 (iMP3) and its correlation with tumor stage and grade in benign urothelium and bladder urothelial carcinomas. Material and Method:The expression of iMP3 in 91 patients with benign urothelium (20 cases), low grade invasive (17 cases) / noninvasive (20 cases) urothelial carcinoma and high grade invasive (20 cases) / non-invasive (14 cases) urothelial carcinoma was evaluated by immunohistochemistry in this study.Results: iMP3 was not expressed in benign urothelium, low-grade non-invasive urothelial carcinoma and high grade non-invasive urothelial carcinoma. Expression of iMP3 was found in 11.76% of low-grade invasive urothelial carcinomas and 55% of high grade invasive urothelial carcinomas. Statistical analysis including χ2 tests showed that iMP3 expression of invasive urothelial carcinomas was statistically significant (p<0.000). Conclusion:The detection of iMP3 only in invasive carcinomas although some of them were low grade showed that the expression of iMP3 may be related to aggressive behavior of urothelial carcinomas.Key Words: Urinary bladder, Urothelial carcinoma, iMP3, Transitional cell carcinoma ÖZ Amaç: Ürotelyal karsinomların %75'i yüzeyel tümörler olarak Ta, Tis ve T1 şeklinde karşımıza çıkmaktadır. Yüzeyel tümörler benign davranış gösterirken, invaziv tümörlerde ise yüksek mortalite oranı bildirilmiştir. Bununla birlikte, Ta ve T1 tümörler, farklı biyolojik davranışlar sergileyebilmektedirler. Bu durum, ürotelyal karsinomların davranışının belirlenmesinde, histopatolojik evre ve dereceye ek olarak, bazı biyolojik belirteçlere ihtiyaç olduğunu göstermektedir. Bu çalışmada amacımız, benign ürotelyum ile mesanenin ürotelyal karsinomlarında insulin like growth factor ii mrna binding Protein 3 (iMP3) ekspresyon profilini belirleyerek, tümörün histopatolojik evresi ve derecesi ile ilişkisini saptamaktır. Gereç ve Yöntem:Bu çalışmada 91 hastaya ait benign ürotelyum (20 olgu), düşük dereceli invaziv (17 olgu) / non-invaziv (20 olgu) ürotelyal karsinom ve yüksek dereceli invaziv (20 olgu) / non-invaziv (14 olgu) ürotelyal karsinom tanısı almış olgular immünohistokimyasal olarak iMP3 ekspresyonu açısından değerlendirildi. Bulgular:Benign ürotelyum, düşük dereceli non-invaziv ürotelyal karsinom ve yüksek dereceli non-invaziv ürotelyal karsinom tanısı almış olgularda iMP3 ekspresyonu saptanmadı. Düşük dereceli invaziv ürotelyal karsinom olgularının %11,76'sında, yüksek dereceli invaziv ürotelyal karsinom olgularının %55'inde...

The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

“…10 The data from the present study support these findings. Cholesterol stones are the most common type of gallstones, and they have been identified as 67.5% of gallstones by Mazlum et al 11 , 70% by Van Erpecum, 3 and 75% by Whiting et al 5 Similarly, we found that 58.7% of the sample gallstones were cholesterol stones. Otherwise, the mean gallstone cholesterol concentration was reported to be 25% by Angwafo et al 12 59.7% by Chandran et al 9 and 60.8% by Jaraari et al 13 We determined that the mean stone cholesterol concentration was 52.1%.…”