Profile of Female Sexual Function: a patient-based, international, psychometric instrument for the assessment of hypoactive sexual desire in oophorectomized women

McHorney, Coleen A; Rust, John; Golombok, Susan; Davis, Susan Ruth; Bouchard, Céline; Brown, Candace; Basson, Rosemary; Sarti, Donati; Kuznicki, James T.; Rodenberg, Cynthia; Derogatis, Leonard R.

doi:10.1097/01.gme.0000109316.11228.77

Cited by 93 publications

(59 citation statements)

References 20 publications

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“…It is designed to assess sexual desire and related domains of women's sexual response over the last 30 days. It has been described in detail elsewhere (10,11). The PFSF has demonstrated excellent discriminate validity (10), good internal consistency, test-retest reliability and appropriate correlation among domains (11).…”

Section: Methodsmentioning

confidence: 99%

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Relationship between hypoactive sexual desire disorder and aging

Hayes

Dennerstein

Bennett

et al. 2007

Fertility and Sterility

198

145

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Section: Methodsmentioning

confidence: 99%

“…It has been described in detail elsewhere (10,11). The PFSF has demonstrated excellent discriminate validity (10), good internal consistency, test-retest reliability and appropriate correlation among domains (11). A cut-off score on the desire domain of the PFSF was used to classify women with low sexual desire.…”

Section: Methodsmentioning

confidence: 99%

Relationship between hypoactive sexual desire disorder and aging

Hayes

Dennerstein

Bennett

et al. 2007

Fertility and Sterility

198

145

View full text Add to dashboard Cite

“…Research on surgical menopausal women has described -if to a lesser extent -somewhat similar events; removal of the ovaries causes a decrease in testosterone levels and sexual desire (22)(23)(24)(25). This psychological process of adjusting to a lower serum level could be of influence on the association between testosterone and sexual desire.…”

Section: Discussionmentioning

confidence: 99%

Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels

Elaut¹,

Cuypere²,

Sutter³

et al. 2008

European Journal of Endocrinology

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Objective: An unknown proportion of transsexual women (defined as post-operative male-to-female transsexuals on oestrogen replacement) experience hypoactive sexual desire disorder (HSDD). It has been suggested that the absence of ovarian androgen production together with oestrogen treatmentrelated increase in sex hormone-binding globulin (SHBG) levels could be leading to HSDD, due to low levels of biologically available testosterone. This study wishes to document the HSDD prevalence among transsexual women and the possible association to androgen levels. Design: Cross-sectional study. Methods: Transsexual women (nZ62) and a control group of ovulating women (nZ30) participated in this study. Questionnaires measuring sexual desire (sexual desire inventory) and relationship and sexual satisfaction (Maudsley Marital Questionnaire) were completed. Serum levels of total testosterone, LH and SHBG were measured in blood samples obtained at random in transsexual women and in the early follicular phase in ovulating women. Results: The transsexual group had lower levels of total and calculated free testosterone (both P!0.001) than the ovulating women. HSDD was reported in 34% of the transsexual and 23% of the ovulating women (PZ0.30). Both groups reported similar levels of sexual desire (PZ0.97). For transsexual women, no significant correlation was found between sexual desire and total (PZ0.64) or free testosterone (PZ0.82). In ovulating women, these correlations were significant (PZ0.006, resp. PZ0.003). Conclusions: HSDD is reported in one-third of transsexual women. This prevalence is not substantially different from controls, despite markedly lower (free) testosterone levels, which argues against a major role of testosterone in this specific group.

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“…31,32 In the development of the PFSF, preliminary items and domains of sexual function were identified through interviews with surgically and naturally menopausal women in the United States and Europe. A subset of items was selected for translation and further analysis.…”

Section: Specific Measures Of Sexual Functionmentioning

confidence: 99%

Assessment of sexual function/dysfunction via patient reported outcomes

Derogatis

2007

Int J Impot Res

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The recent recognition of the high prevalence of sexual dysfunctions and disorders in our society, along with the substantial investment of the pharmaceutical industry in the field of sexual functioning, has resulted in a significant expansion in the development of valid and reliable measures of sexual function/dysfunction. The instruments tend to be brief self-report inventories, typically requiring 10-20 min of patient time for completion. Most measures were initially developed as screening and outcomes measures for use in clinical drug trials of new treatments for sexual dysfunction, but are beginning to see more widespread use in the clinic. All these instruments must adhere to recently prescribed rigorous guidelines set forth by the Food and Drug Administration, and have been demonstrated to be valid and reliable indicators of the status and quality of sexual functioning in both men and women. The constructs that form the framework of our diagnostic system for sexual dysfunctions are not amenable to direct physical measurement, so that currently they must be assessed via these self-report scales. Although not as precise as physical measures, these inventories do an admirable job of quantifying and registering sexual functioning status in a concise and reliable manner, and have become indispensable tools in our clinical and research programs.

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Profile of Female Sexual Function: a patient-based, international, psychometric instrument for the assessment of hypoactive sexual desire in oophorectomized women

Cited by 93 publications

References 20 publications

Relationship between hypoactive sexual desire disorder and aging

Relationship between hypoactive sexual desire disorder and aging

Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels

Assessment of sexual function/dysfunction via patient reported outcomes

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