Profile of Coronary Vasodilator and Cardiac Actions of Bepridil Revealed by Use of Isolated, Blood-Perfused Heart Preparations of the Dog

Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs

“…Considering that bepridil has been reported to show a lidocaine-like fast kinetic block of Na + current, 37,38 this mechanism may be associated with the ventricular conduction delay. 24,39 Bepridil caused a negative dromotropic effect after the high dose, which is in accordance with previous reports, 15,16,40 suggesting that the drug can inhibit Ca 2+ channels in vivo. 21,41 However, its potency during the sinus rhythm was weaker than that of dl-sotalol, based on the current results.…”

Interactions Between Calcium Entry Blockers and Vecuronium Bromide in Anaesthetized Cats

“…The inability of nifedipine readily to penetrate either smooth or cardiac muscle cells (Pang and Sperelakis, 1983) suggests that a direct action on contractile proteins in skeletal muscle seems unlikely also. Nifedipine, verapamil and bepridil differ markedly in potency regarding their ability to inhibit calcium channels in smooth muscle (Kawada, Satoh and Taira, 1983). The present observation that equiactive vasodilator doses of these three calcium entry blockers produce similar potentiation of the neuromuscular blocking actions of vecuronium suggests that blockade of calcium channels in skeletal muscle may be involved in the observed interactions.…”

“…The doses of the calcium entry blockers were chosen to produce similar decreases in arterial pressure, an effect caused by their blocking action on calcium channels in peripheral vascular smooth muscle (Stone et al, 1980). In keeping with their different relative selectivities for calcium channels in cardiac muscle (Henry, 1980;Kawada, Satoh and Taira, 1983), only bepridil produced a marked and sustained bradycardia. In contrast to their effects on calcium channels in vascular smooth or cardiac muscle, or both, none of the calcium entry blockers significantly modified neuromuscular transmission per se.…”

Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem

“…Similar effects on 'slow structures' have also been demonstrated with bepridil in vivo (Beaughard et al, 1982;Kawada et al, 1983) and, in vitro studies in cardiac muscle have shown that this compound preferentially inhibits slow calcium currents (Labrid et al, 1979;Yatani et al, 1986). Such an action could explain the effect of bepridil on 'slow structures' observed in the present study.…”