Profile of Cases of Infectious Meningitis in Hiv Patients

Abstract

BACKGROUND Central nervous system (CNS) involvement is one of the common manifestations of acquired immunodeficiency syndrome (AIDS). About one-fifth of AIDS patients die of CNS diseases. MATERIALS AND METHODS A hospital-based cross-sectional descriptive study was conducted in Rajiv Gandhi Institute of Medical Sciences, Ongole. 50 HIV patients with clinical features suggestive of meningitis were selected for the study. A brief history and detailed investigations were carried out for the patients. RESULTS Out of the 50 study population, majority (56%, n= 28) belonged to 30-39 years' age group and majority (60%, n= 30) were females. Tuberculous meningitis was found to be the most common cause of meningitis in HIV patients. In the present study, 30 patients (60%) were found to have tuberculous meningitis and 5 patients (10%) were found to have cryptococcal meningitis. 46 patients had CD4+ T-cell count < 500/uL, among whom 18 patients had CD4+ T-cell count < 200/uL. All the patients with tuberculous meningitis and cryptococcal meningitis were found to have CD4 count < 500/uL. CONCLUSION Tuberculous meningitis was found to be the most common cause of meningitis in HIV patients.

Evaluation of Central Nervous System Infections in HIV/AIDS Patients: A Seven-Year Retrospective Analysis

“…Genel olarak SSS infeksiyonları CD4 + 200 hücre/μl altında görülmektedir (5). Nörolojik semptomlar %10-20 oranıyla AIDS'in ilk bulgularıdır ve günümüzde AIDS olgularının beşte biri SSS infeksiyonları nedeniyle yaşamını yitirmektedir (6). Yüksek mortalite kadar ciddi morbiditeye neden olan SSS infeksiyonları hastanın hayat kalitesini düşürmesi ve yüksek sağlık maliyetlerine sebep olması yönüyle de önem arz etmektedir.…”