Profile measurements of MeV ion microbeams in atmosphere extracted from single tapered glass capillaries with an end window

Ikeda, Tokihiro; Ikekame, Mayuka; Hikima, Yuka; Mori, Mitsumasa; Kawamura, Shunya; Minowa, Tatsuya; Jin, Wei–Guo

doi:10.1016/j.nimb.2020.03.004

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…Microbeam facilities for biological experiments have been developed and used in many institutions worldwide [5][6][7][8][9][10][11][12][13][14], but most have precisely focused on studying irradiated individual cultured cells and analyzing their responses [5,15]. In contrast, our device has been used to study various individual organisms, such as Caenorhabditis elegans (C. elegans) [16][17][18][19][20][21], medaka fish [22][23][24], silkworms [25,26], and Arabidopsis [27], in addition to studies with cultured cells.…”

Section: Introductionmentioning

confidence: 99%

A Method to Locally Irradiate Specific Organ in Model Organisms Using a Focused Heavy-Ion Microbeam

Funayama,

Suzuki,

Miyawaki

et al. 2023

Biology

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The functions of organisms are performed by various tissues composed of different cell types. Localized irradiation with heavy-ion microbeams, which inactivate only a portion of the constituent cells without destroying the physical intercellular connections of the tissue, is a practical approach for elucidating tissue functions. However, conventional collimated microbeams are limited in the shape of the area that can be irradiated. Therefore, using a focused heavy-ion microbeam that generates a highly precise beam spot, we developed a technology to uniformly irradiate specific tissues of an organism with a defined dose, which conventional methods cannot achieve. The performance of the developed paint irradiation technology was evaluated. By irradiating the CR-39 ion track detector, we confirmed that the new method, in which each ion hit position is placed uniformly in the irradiated area, makes it possible to uniformly paint the area at a specified dose. The targeted irradiation of the pharynx and gonads of living Caenorhabditis elegans demonstrated that the irradiated ions were distributed in the same shape as the targeted tissue observed under a microscope. This technology will elucidate biological mechanisms that are difficult to analyze with conventional collimated microbeam irradiation.

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Section: Introductionmentioning

confidence: 99%

A Method to Locally Irradiate Specific Organ in Model Organisms Using a Focused Heavy-Ion Microbeam

Funayama,

Suzuki,

Miyawaki

et al. 2023

Biology

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show abstract

“…First results in the field of sliding interaction of charged particle beams with dielectric surfaces were obtained in paper [1], which described the effect of control (guiding) of an ion beam using a polymer film with nanocapillaries. The first research results in the field of controlling electrons with energies below 1 keV using nanocapillaries were presented in 2007 in studies [2,3].…”

Section: Introductionmentioning

confidence: 99%

Rotation of the 10 keV Electron Beam By 360° Using PVC Tubes

et al. 2022

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We measured the time dependence of the passage of an electron beam with an energy of 10 keV and a beam current of about 1.8 μA through PVC tubes bent into rings by 360°. The tubes with the following parameters were used: one with the inner diameter of the tube 2.8 mm, the diameter of the ring 75 mm; and another with an inner diameter of 4 mm, and a ring diameter of 150 mm. In both cases, the current of transmitted electrons was about 15% of the incident current. Measurement of the electron spectrum for a ring of smaller diameter showed that all electrons that passed through it lose their initial energy.

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“…Despite that pure electrostatic guiding or focusing of MeV ions with capillaries of various shapes has still many open questions to solve, several laboratories built their home-made "capillary setup" for focusing ion beams for ion-beam analysis [6], for ion beam modification of materials [7], or for ion irradiation of living cells [8]. Development of these setups for new applications is continuously under way [9,10], nevertheless, to overcome experimental difficulties, it is also important to continue fundamental research, which reveals underlying processes and thus helps us in the design and construction of operational devices.…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal distribution of a 1-MeV proton microbeam guided through a poly(tetrafluoroethylene) macrocapillary

et al. 2021

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We present computer simulations about the spatial and temporal evolution of 1 MeV proton microbeam transmitted through an insulating macrocapillary with the length of 45 mm and with the inner diameter of 800 μm. The axis of the capillary was tilted to 1° relative to the axis of the incident beam, which ensured geometrical non-transparency. The simulation is based on the combination of stochastic (Monte-Carlo) and deterministic methods. It involves 1) random sampling of the initial conditions, according to distributions generated by the widely used and freely available computer software packages, SRIM and WinTRAX, 2) the numerical solution of the governing equations for following the classical trajectory of the projectiles, and 3) the description of the field-driven charge migration on the surface and in the bulk of the insulator material. We found that our simulation describes reasonably all of our previous experimental observations, indicating the functionality and reliability of the applied model. In addition, we found that at different phases of the beam transmission, different atomic processes result in the evolution of the beam distribution. First, in a scattering phase, the multiple small angle atomic scattering dominates in the beam transmission, resulting an outgoing beam into a wide angular range and in a wide energy window. Later, in a mixed phase, scattering and guiding happens simultaneously, with a continuously increasing contribution of the guiding. Finally, in the phase of the stabilized, guided transmission, a quadrupole-like focusing effect is observed, i.e. the transmitted beam is concentrated into a small spot, and the transmitted protons keep their initial kinetic energy.

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Profile measurements of MeV ion microbeams in atmosphere extracted from single tapered glass capillaries with an end window

Cited by 13 publications

References 15 publications

A Method to Locally Irradiate Specific Organ in Model Organisms Using a Focused Heavy-Ion Microbeam

A Method to Locally Irradiate Specific Organ in Model Organisms Using a Focused Heavy-Ion Microbeam

Rotation of the 10 keV Electron Beam By 360° Using PVC Tubes

Spatial and temporal distribution of a 1-MeV proton microbeam guided through a poly(tetrafluoroethylene) macrocapillary

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