Profile and risk factors for congenital heart defects: A study in a tertiary care hospital

Abqari, Shaad; Gupta, Akash; Shahab, Tabassum; Rabbani, M U; Ali, Syed S.; Firdaus, Uzma

doi:10.4103/0974-2069.189119

Cited by 66 publications

(68 citation statements)

References 14 publications

(18 reference statements)

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“…4,5 The prevalence of congenital heart disease was found to be 5.8/1000 hospitalized patients by Shah GS et al, 13.28% by Sawant SP et al conducted at Mumbai whereas in the present study it was 6.49%. 5,6 Acyanotic heart disease constituted 27.50% of the congenital heart disease according to Abquari S. 4 In the present study the prevalence was found to be 13.69%. A study by Shah GS estimated the prevalence of cyanotic congenital heart disease to be 31%.…”

Section: Discussioncontrasting

confidence: 49%

“…The prevalence of congenital diaphragmatic hernia in this study was found to be 2.66/10000 live births, whereas that in a study done by Burgos CM et al in Sweden, it was found to be 3.5/10000 deliveries, and in a study done by Grizelj R et al in Croatia it was found to be 2.67/10000 live births. 4,10 In this study the prevalence of structural congenital anomalies at the time of birth before discharge were analyzed.…”

Section: Discussionmentioning

confidence: 99%

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A cross sectional study on the prevalence of structural congenital anomalies among neonates delivered in a tertiary care hospital, Chennai from January 2016 to February 2017

Muthu¹,

Kumar²,

Ponnappan³

2017

Int J Contemp Pediatr

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Background: Congenital anomalies are important contributors to infant and childhood deaths, chronic illness and disability. The pattern and type of anomaly varies regionally. The planning and the implementation of public health programs for congenital anomalies are dependent on the prevalence data. Adequate data is unavailable in our country. The objective of this study was to study the prevalence of congenital anomalies and the factors influencing them, in Government RSRM lying in hospital, Chennai from January 2016 to February 2017. Methods: This is a cross-sectional study conducted in Government RSRM lying-in hospital, a tertiary care neonatal unit, from January 2016 to February 2017. The case records of neonates delivered during the study period were studied to identify those with congenital anomalies. The factors possibly influencing congenital anomalies were studied. Results: The number of case records analyzed was 11242, out of which 157 neonates were reported to have structural congenital anomalies; the prevalence was 1.4%. Congenital heart disease formed the majority, 46.5% (73/157) of congenital anomalies identified. The most common extra-cardiac congenital anomalies noted were cleft lip/cleft palate (15/157) 9.6%, followed by single umbilical artery which was noted in 5.7% (9/157). Down's syndrome was seen in 3.8% (6/157) and neural tube defects in 3.2% (5/157) of the babies with congenital anomalies. Conclusions: The prevalence of commonly occurring congenital anomalies in the study hospital was comparable to the prevalence in other similar studies in India. The prevalence of neural tube defects was lower in our area compared to other countries whereas, that of acyanotic heart diseases were higher than in other studies.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

A cross sectional study on the prevalence of structural congenital anomalies among neonates delivered in a tertiary care hospital, Chennai from January 2016 to February 2017

Muthu¹,

Kumar²,

Ponnappan³

2017

Int J Contemp Pediatr

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“…9 We have also observed an increase in the number of ASD (16.88%) as the second common CHD. This may be attributable to over-diagnosis of patent foramen ovale as atrial septal defect.…”

Section: Discussionmentioning

confidence: 57%

“…9 Some studies shows the male preponderance of 2.08:1 and 1.78:1 but we didn't get a significant gender disparity (1.2:1). 10,11 This small disparity may be explained on basis of social issue in our country, which may be due to high health seeking behaviour in parents for male child.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of congenital heart disease in a tertiary care centre of Eastern India

Mahapatra

Sarangi

Mahapatra

2017

Int J Contemp Pediatr

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Background: Congenital heart disease (CHD) is not an uncommon entity in our country. The prevalence of CHD is 9.3 per 1000 life birth in Asia which is found to be highest globally. Not much of Indian data is available particularly from this part of the country. So we conduct a retrospective study to know the spectrum of congenital heart disease in our set up.Methods: This is a retrospective hospital based study carried out over a period of 20 months (2015 March - 2016 November) where all suspected children (< 14 years) of CHD were subjected to echocardiographic study. The age, sex, clinical presentation and echo findings were well documented. Results: The total number CHD diagnosed were 231 and were more common among males (54.5%) with male to female ratio is 1.2:1. CHD were diagnosed more commonly between 1 month to 1 Year (40.25%). The commonest type of acyanotic CHD in our study was ventricular septal defect (VSD) (36.3%) and cyanotic CHD is tetralogy of Fallot (11.25%). The major clinical finding was a detection of a murmur (84.8%) followed by tachycardia (41.5%) and tachypnea (36.3%).Conclusions: In this era of most accurate diagnostic modalities, any clinical suspicion of congenital heart disease should be confirmed by echocardiography to hasten the diagnosis, timely management and prevention of complications.

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“…We identified 31 studies published between 1990 and 2018 according to the inclusion criteria. Study selection was summarized in Figure .…”

Section: Resultsmentioning

confidence: 99%

The non‐genetic paternal factors for congenital heart defects: A systematic review and meta‐analysis

Peng

Meng

Zhou

et al. 2019

Clinical Cardiology

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Background Advances have been made in identifying genetic etiologies and maternal risk factors of congenital heart defects (CHDs), while few literatures are available regarding paternal risk factors for CHDs. Thus, we aim to conduct a meta‐analysis and systematic review about the non‐genetic paternal risk factors for CHDs. Methods We searched the PubMed, MEDLINE, and Cochrane Library online databases and identified 31 studies published between 1990 and 2018 according to the inclusion criteria. Paternal risk factors were divided into subgroups, and summarized odd ratios (OR) were calculated. Results Paternal age between 24 and 29 years decreased the risk of CHDs in the offspring (OR = 0.90 [0.82, 0.98]), while paternal age ≥ 35 years old increased the risk of CHDs (35‐39 years old: OR = 1.14 [1.09, 1.19], and ≥ 40 years: OR = 1.27 [1.14, 1.42]). Paternal cigarette smoking increased the risk of CHDs in a dose‐dependent way. Paternal wine drinking (OR = 1.47 [1.05, 2.07]) and exposure to chemical agents or drugs (OR = 2.15 [1.53, 3.02]) also increased the risk of CHDs. Some specific paternal occupations were also associated with increased risk for CHDs or CHD subtypes including factory workers, janitors, painters, and plywood mill workers. Conclusions This meta‐analysis and systematic review suggested that advanced paternal age, cigarette smoking, wine drinking, exposure to chemical agents or drugs and some specific occupations were associated with an increased risk of CHDs. More measures should be taken to reduce occupational and environment exposures. At the same time, fertility at certain age and establishment of healthy life habits are strongly recommended.

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Profile and risk factors for congenital heart defects: A study in a tertiary care hospital

Cited by 66 publications

References 14 publications

A cross sectional study on the prevalence of structural congenital anomalies among neonates delivered in a tertiary care hospital, Chennai from January 2016 to February 2017

A cross sectional study on the prevalence of structural congenital anomalies among neonates delivered in a tertiary care hospital, Chennai from January 2016 to February 2017

Spectrum of congenital heart disease in a tertiary care centre of Eastern India

The non‐genetic paternal factors for congenital heart defects: A systematic review and meta‐analysis

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