Profile and histopathology features of top three cases of Extra Pulmonary Tuberculosis (EPTB) in West Nusa Tenggara: A retrospective cross-sectional study

Djannah, Fathul; Massi, Muhammad Nasrum; Hatta, Mochammad; Bukhari, Agussalim; Hasanah, Idyatul

doi:10.1016/j.amsu.2022.103318

Cited by 7 publications

(6 citation statements)

References 22 publications

(25 reference statements)

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“…Sreeramareddy et al, have found that female patients were more likely to have EPTB in Nepal, a developing country [19]. Also, Djannah et al, have shown that the incidence of EPTB in women is higher than in men in Indonesia [20]. In our study, the female gender is dominant at the rate of 69%.…”

Section: Discussionsupporting

confidence: 57%

Demographic and microbiological characteristics of tuberculous lymphadenitis and other extrapulmonary tuberculosis cases

ALTUNAL

Şengel

OZEL

et al. 2022

Marmara Medical Journal

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Objective: Tuberculosis (TB) is a significant public health problem that remains important worldwide. This study aimed to examine the demographic characteristics and clinical features of patients with extrapulmonary tuberculosis (EPTB) and also identify the comorbidities of EPTB. Our secondary aim was to compare tuberculous lymphadenitis (TBL) with other forms of EPTB. Patients and Methods: This single-center, retrospective, observational study was conducted on patients diagnosed with EPTB in a training hospital in Turkey between January 1, 2011 and December 31, 2020. The demographic characteristics and clinical features of the patients were examined. TBL cases were compared with other forms of EPTB cases. Results: The most common clinical form was TBL. Fever, night sweats, and accelerated erythrocyte sedimentation rate were significantly more common in the other forms of the EPTB group compared to TBL. The rate of tuberculin skin test positivity was significantly higher in patients with TBL. The complication rate was 3%, and mortality rate was 4% among all patients. Conclusions: Extrapulmonary tuberculosis should be considered in the differential diagnosis by evaluating the medical history of patients who present with organ-specific symptoms, especially in TB endemic countries. The clinic may differ according to the organ involvement. TBL may be seen with milder symptoms compared to other clinical forms.

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Section: Discussionsupporting

confidence: 57%

Demographic and microbiological characteristics of tuberculous lymphadenitis and other extrapulmonary tuberculosis cases

ALTUNAL

Şengel

OZEL

et al. 2022

Marmara Medical Journal

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“…On the other hand, POG was established when the necrotic materials found were histiocyte cell, lymphoid mature cell or polymorphonuclear neutrophils (PMN) cells without epithelioid cells or Langhans giant cells. (5,20)…”

Section: Wog and Pog Classificationmentioning

confidence: 99%

Well-organized Granuloma Lymphadenitis Tuberculosis Expressed Lower Macrophage Migration Inhibitory Factor (MIF) Score Compared to the Poorly-organized Granuloma

et al. 2023

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BACKGROUND: The case of extra-pulmonary tuberculosis (EPTB) is common and the most type of extra-pulmonary tuberculosis found is lymphadenitis TB (LnTB). Macrophage migration inhibitory factor (MIF) is correlated with TB, and low level of MIF was correlated to Mycobacterium TB bacteremia. Deficiency of MIF macrophage is known to be correlated to the increased of a lung pathology; however, its role on pathogenesis LnTB remains unclear. Hence, this study was conducted to analyze the correlation of MIF in several type of granuloma organization in LnTB.METHODS: Block paraffin of the lymphoid tissue infected with M. Tuberculosis were analyzed with immunohistochemistry (IHC) to assess the MIF expression, by counting the immunoreactivity score (IRS) according to the intensity of stained cells and the level of staining. The histopathology type of LnTB was divided into well-organized granuloma (WOG) and poorly-organized granuloma (POG) based on the granuloma characteristics.RESULTS: Among 100 tissues samples that fulfilled the study criteria, WOG was found in 51% cases. MIF was expressed mild positive in 21% samples, on the other hand, 79% was not expressed. There was a significant difference of MIF negative, as was found in 98% of WOG group while only 59% was found in POG group (p<0.001).CONCLUSION: There is a significant correlation between MIF expression with the type of granuloma organization in LnTB. The expression of MIF in WOG group is mostly negative, as well as a half of the POG group. This results may suggests that MIF plays a role in the pathogenesis of granuloma formation in LnTB.KEYWORDS: MIF, lymphadenitis TB, WOG, POG, immunohistochemistry

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“…Intestinal TB, bone TB, and cervical lymphadenitis TB are examples of extrapulmonary TB (EPTB), which can also present beyond the lungs. Cervical lymphadenitis TB is the most prevalent kind of EPTB observed in Indonesia, and the majority of cases were well-organized granulomas [ 1 , 2 ]. Approximately 15%–20% of all TB cases in individuals with immunocompromised status and >50% of cases in HIV-positive individuals are caused by EPTB [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…This study aimed to determine the difference between miR-425-5p and miR-4523 in active pulmonary TB (PTB), latent TB (LTBI), and extrpulmonary TB (EPTB), whose diagnosis remains challenging. We also examined lymph node TB (LNTB), which is the most frequent EPTB found in Indonesia [ 1 , 2 ]. The results of this study are expected to assist in the development of biomarkers for the early diagnosis of active PTB, EPTB, and LTBI.…”

Section: Introductionmentioning

confidence: 99%

microRNA hsa-miR-425-5p and hsa-miR-4523 expressions as biomarkers of active pulmonary tuberculosis, latent tuberculosis infection, and lymph node tuberculosis

Massi

Hidayah²,

Handayani

et al. 2023

Non-coding RNA Research

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Profile and histopathology features of top three cases of Extra Pulmonary Tuberculosis (EPTB) in West Nusa Tenggara: A retrospective cross-sectional study

Cited by 7 publications

References 22 publications

Demographic and microbiological characteristics of tuberculous lymphadenitis and other extrapulmonary tuberculosis cases

Demographic and microbiological characteristics of tuberculous lymphadenitis and other extrapulmonary tuberculosis cases

Well-organized Granuloma Lymphadenitis Tuberculosis Expressed Lower Macrophage Migration Inhibitory Factor (MIF) Score Compared to the Poorly-organized Granuloma

microRNA hsa-miR-425-5p and hsa-miR-4523 expressions as biomarkers of active pulmonary tuberculosis, latent tuberculosis infection, and lymph node tuberculosis

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