Profilaxia com descolonização nasal em pacientes submetidos a artroplastia total de joelho e quadril: revisão sistemática com metanálise

Sadigursky, David; Pires, Henrique Santos; Rios, Saulo Américo Caldas; Filho, Francisco Luiz Borja Rodrigues; Queiroz, Gustavo Castro de; Azi, Mateus Lemos

doi:10.1016/j.rbo.2016.10.013

Cited by 8 publications

(1 citation statement)

References 27 publications

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“…Therefore, the susceptibility of LA-MRSA to antiseptics is an important issue, as LA-MRSA is an emerging problem and antiseptic agents are valuable drugs for prevention of MRSA infections [18, 35]. For example, antiseptic decolonization has been proven to control the spread of MRSA in intensive care healthcare settings [8] and to reduce surgical site infections [36]. Nevertheless, the effectiveness of these measures relies on the susceptibility of the targeted pathogens to the antiseptic products used.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparison

Dittmann

Schmidt

Müller

et al. 2019

Antimicrob Resist Infect Control

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Background Recent publications have raised concerns of reduced susceptibilities of clinical bacterial isolates towards biocides. This study presents a comparative investigation of the susceptibility of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA), hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA) to the commonly used antiseptics chlorhexidine (CHX), octenidine (OCT), polyhexanide (PHMB), PVP-iodine (PVP-I) and triclosan (TCX) based on internationally accepted standards. Methods In total, 28 (18 LA-, 5 HA- and 5 CA) genetically characterized MRSA strains representing a broad spectrum of hosts, clonal complexes and spa-types, as well as the reference methicillin-sensitive Staphylococcus aureus (MSSA) strain ATCC 6538, were selected. Minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MBC) were determined in accordance with DIN 58940–7, 58940–8 and DIN EN ISO 20776-1. The microbicidal efficacy was determined in accordance with DIN EN 1040. Results Results from the MIC/MBC and quantitative suspension tests revealed differences between antiseptic substances but not between epidemiological groups of MRSA strains. OCT and PHMB were the most active substances with a minimal MIC of 1 mg/L, followed by CHX (2 mg/L), TCX (32 mg/L) and finally PVP-I (1024 mg/L). The MSSA reference strain showed a tendency to a higher susceptibility compared to the MRSA strains. Conclusions This investigation of the susceptibility of a range of LA-, HA- and CA-MRSA strains using standardized conditions gave no indication that LA-MRSA strains are less susceptible to commonly used antiseptics compared to HA- and CA-MRSA strains.

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