Profil épidémiologique, clinique et thérapeutique des tumeurs stromales gastro-intestinales

Pratic, Fatima; Ouarrach, Houda; Samlani-Sebbane, Z.; Oubaha, Sofia; Krati, K.

doi:10.1007/s12157-017-0718-4

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…However, GISTs usually affect both genders without predilection [3]. Other studies from Africa with small sample size reported similar results [3,7,15].…”

Section: Discussionmentioning

confidence: 65%

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Gbéssi

Gnangnon

Kpossou

et al. 2021

Preprint

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Background: GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa there are few studies about it. This study described the diagnosis and therapeutic management of GIST in Cotonou, Benin.Methods: This was a descriptive cross-sectional study, with retrospective data collection over a 10-year period from 2010 to 2020, focused on patients with histological confirmed gastro-intestinal stromal tumor (GIST). Data analysis was performed with Epidata Analysis software version 3.0.0.1.Results: Fifteen GISTs were identified during the study period. The median age was 52 and the sex ratio was 2. The most frequent symptom was abdominal pain (n = 12). Delay in care seeking after onset of symptoms ranged from 24 hours to 15 years. The most common site for GISTs was the stomach (n = 8). The median tumor size was 11 cm and the majority (n=10) was metastatic or locally advanced at the time of diagnosis. The tumors were often spindle-shaped at histology (n = 13) and the majority expressed KIT (n = 14). Most of the tumors (n = 12) were at high risk of recurrence according to the Joensuu scoring system. The availability of imatinib have improved the outcome of GIST with response in all cases it was used in neoadjuvant setting (n = 7).Conclusion: GISTs are rare tumors and preferentially affect the stomach in Cotonou. Most of the tumors were large, unresectable at the time of diagnosis and at high risk of recurrence. Access to imatinib has revolutionized the management of those tumors in our country.

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“…However, GISTs usually affect both genders without predilection [3]. Other studies from Africa with small sample size reported similar results [3,7,15].…”

Section: Discussionmentioning

confidence: 65%

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Gbéssi

Gnangnon

Kpossou

et al. 2021

Preprint

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show abstract

“…However, GISTs usually affect both genders without predilection [3]. Other studies from Africa with a small sample size reported similar results [3,7,15].…”

Section: Discussionmentioning

confidence: 77%

Challenge of gastro-intestinal stromal tumor management in low-income countries: example of Benin

et al. 2022

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Background GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa, there are few studies about it. Imatinib, an oral targeted therapy, has been available in Benin since 2010 and free since 2016. This study describes the diagnosis and therapeutic management of GIST in Cotonou, Benin. Methods This is a descriptive cross-sectional study, with retrospective data collection over a 10-year period from 2010 to 2020, focused on patients with histological confirmed gastro-intestinal stromal tumor (GIST). Cases were identified using the registry database and the archival files of the Hubert Koutoukou Maga National University Hospital of Cotonou (CNHU-HKM). Results Fifteen GISTs were identified during the study period. The median age was 52 and the sex ratio was 2:1 (10 males and 5 females). The most frequent symptom was abdominal pain (n = 12). Delay in care seeking after onset of symptoms ranged from 24 h to 15 years. The most common site for GISTs was the stomach (n = 8). The median tumor size was 11 cm and the majority (n=10) was metastatic or locally advanced at the time of diagnosis. The tumors were often spindle-shaped at histology (n = 13) and the majority expressed KIT (n = 14). Most of the tumors (n = 12) were at high risk of recurrence according to the Joensuu scoring system. The availability of imatinib has improved the outcome of GIST with response in all cases it was used in neoadjuvant setting (n = 7). Conclusion GISTs are rare tumors and preferentially affect the stomach in Cotonou). Most of the tumors were large, unresectable at the time of diagnosis and at high risk of recurrence. Access to imatinib has revolutionized the management of those tumors in our country.

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“…A notre connaissance, notre travail est l'une des rares études qui se sont intéressées à l'analyse du profil épidémiologique et les aspects cliniques et thérapeutiques des GIST au Maroc [5,6,8]. On a montré que la fréquence des GIST dans notre centre hospitalier était de 3,8 cas chaque année, ce qui rejoint les données d'un autre centre à Marrakech qui rapportait une incidence de 2,8 et 3,15 cas par an, respectivement dans deux travaux publiés en 2013 [8] et 2017 [6] alors que dans un autre centre à Casablanca qui est la plus grande ville du Maroc, l'incidence était de 6,5 cas par an [5].…”

Section: Discussionunclassified

“…On a montré que la fréquence des GIST dans notre centre hospitalier était de 3,8 cas chaque année, ce qui rejoint les données d'un autre centre à Marrakech qui rapportait une incidence de 2,8 et 3,15 cas par an, respectivement dans deux travaux publiés en 2013 [8] et 2017 [6] alors que dans un autre centre à Casablanca qui est la plus grande ville du Maroc, l'incidence était de 6,5 cas par an [5]. Les GIST surviennent à un âge médian de 60 ans et sans prédominance de sexe [2,9].…”

Section: Discussionunclassified

“…Historiquement, ces tumeurs ont été diagnostiquées à tort comme des léiomyomes, des léiomyosarcomes ou des léiomyoblastomes jusqu'à l'identification des mutations c-Kit et du récepteur du facteur de croissance dérivé des plaquettes (PDGFR) [4]. Bien que les GIST soient les sarcomes les plus fréquents du tube digestif (80 %), elles ne représentent toutefois que 0,1 à 3 % de tous les cancers digestifs avec une incidence mondiale estimée seulement entre 1 et 1,5 pour 100 000 habitants/an [2,5,6]. En l'absence d'un registre national actif sur le cancer au Maroc, nous rapportons le profil épidémiologique des GIST et nous présentons une analyse de leurs données anatomocliniques, thérapeutiques et évolutives à travers l'expérience de vie réelle d'un centre marocain sur 6 ans.…”

Section: Introductionunclassified

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Les tumeurs stromales gastro-intestinales : expérience de vie réelle d’un centre marocain

Bazine¹,

Fetohi²,

Namad³

et al. 2018

Hegel

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Profil épidémiologique, clinique et thérapeutique des tumeurs stromales gastro-intestinales

Cited by 4 publications

References 15 publications

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Challenge of Gastro-Intestinal Stromal Tumor Management in Low-Income Countries : Example of Benin

Challenge of gastro-intestinal stromal tumor management in low-income countries: example of Benin

Les tumeurs stromales gastro-intestinales : expérience de vie réelle d’un centre marocain

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