Proficiency of Khanduchakka Ghrit in the management of Parikartika: A case report

Tichkule, Suraj V; Khandare, Kiran; Shrivastav, Pooja

doi:10.4103/jism.jism_11_19

Cited by 4 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The follow up was also conducted after 30 and 45 days. Even during follow up assessment no signs of recurrence were reported [220]. A broad antimicrobial spectrum of barks and leaves can be a probable rationale for its wound healing property.…”

Section: Wound Healing Activitymentioning

confidence: 88%

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis

et al. 2021

View full text Add to dashboard Cite

Ehretia laevis Roxb. (Boraginaceae) has been extensively used as a traditional remedy for the treatment of a diverse range of ailments related to the respiratory system, the gastrointestinal tract, the reproductive system, and against several infections. This review critically assesses and documents, for the first time, the fragmented information on E. laevis, including its botanical description, folklore uses, bioactive phyto metabolites and pharmacological activities. The goal is to explore this plant therapeutically. Ethnomedicinal surveys reveal that E. laevis has been used by tribal communities in Asian countries for the treatment of various disorders. Quantitative and qualitative phytochemical investigations of E. laevis showed the presence of important phytoconstituents such as pentacyclic triterpenoids, phenolic acids, flavonoids, fatty acids, steroids, alkaloids, aliphatic alcohols, hydrocarbons, amino acids, carbohydrates, vitamins and minerals. Fresh plant parts, crude extracts, fractions and isolated compounds have been reported to exhibit broad spectrum of therapeutic activities viz., antioxidant, antiarthritic, antidiabetic, anti-inflammatory, antiulcer, antidiarrheal, antidysenteric, wound healing and anti-infective activities. E. laevis is shown to be an excellent potential source of drugs for the mitigation of jaundice, asthma, dysentery, ulcers, diarrhea, ringworm, eczema, diabetes, fissure, syphilis, cuts and wounds, inflammation, liver problems, venereal and infectious disorders. Although few investigations authenticated its traditional uses but employed uncharacterized crude extracts of the plant, the major concerns raised are reproducibility of therapeutic efficacy and safety of plant material. The outcomes of limited pharmacological screening and reported bioactive compounds of E. laevis suggest that there is an urgent need for in-depth pharmacological investigations of the plant.

show abstract

Section: Wound Healing Activitymentioning

confidence: 88%

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recently, a case report has been published for the topical application of E. leavis in the management of anal fissure (Parikartika) [114,115]. It was invented that after all the obligatory procedures, the efficacy of E. laevis had been assessed on the basis of parameters like itching, bleeding, pain and healing.…”

Section: Ehretia Laevismentioning

confidence: 99%

Mechanistic Insights and Therapeutic Potential of Natural Products in Amelioration of Wound Healing

Sharma¹,

Kumar²,

Shri³

et al. 2023

Preprint

View full text Add to dashboard Cite

Wound healing is a process through which skin maintains itself. Once a wound occurs, the inflammatory and proliferative stages are instigated in reaction to injury. It is established that wound restorative comprises four stages including haemostasis, inflammation, proliferation, and remodeling. The amelioration of wound healing is very challenging as tumors can develop at the site of chronic injury. There are numerous plants, plant extracts and plant based natural products were widely used by tribal communities from ancient times for the treatment of cuts, burns, scars, burns and wounds. The therapeutic potential of these plants is recognized due to the presence of phytomolecules such as phenolic compounds, flavonoids, triterpenoids, saponins, tannins, alkaloids and glycosides. The plant used for the treatments of wound healing includes Achillea millefolium, Andrographis paniculata, Boswellia sacra, Calendula officinalis, Crocus sativus, Curcuma longa, Ehretia laevis, Ehretia microphylla, Glycyrrhiza glabra, Malva sylvestris, Rosmarinus officinalis and Salvia officinalis. This assemblage comprises the structures of phytomolecules isolated from the different extracts of these plants, mechanistic insights and important key findings responsible for wound healing. The mechanistic insights involved in wound healing are similar to cytotoxic, anti-inflammatory and antioxidant agents such as ROS generation, DNA fragmentation and western blotting. This review article is an effort to bridge the gaps in the prevailing literature and thus offers gigantic scope for researchers and academicians betrothed in validation of the customary claims and development of safer and efficient and worldwide recognized natural potential candidates as drugs for healing of wounds, burns and cuts.

show abstract

“…Burning sensation were graded from 0-3 [5] Grade 0 -No burning sensation Grade 1 -Mild burning sensation Grade 2 -Moderate burning sensation Grade 3 -Severe Burning sensation.…”

Section: Pain Was Assessed By Using Vas Scalementioning

confidence: 99%

“…Discharge was graded from 0-3 [5] Grade 0 : No discharge UCT -Unit Cutting Time Calculation [6] Total number of days required for complete cutting of tract / Initial length of the tract in cm.…”

Section: Pain Was Assessed By Using Vas Scalementioning

confidence: 99%

A randomized, controlled clinical study to evaluate the role of Sarjarasa Apamarga Ksharasutra in the management of Bhagandara w.s.r to fistula-in-ano

TS¹,

Sweta²,

Surendranath³

2022

J Ayurveda Integr Med Sci

View full text Add to dashboard Cite

Fistula-in-ano is one of the most common ailments pertaining to ano-rectal region, is prevalent all over the world and its occurance is 8.6 cases per 100,000 population.[1] The main cause known for fistula-in-ano is crypto glandular infection of anal crypts. In Ayurveda, according to similar clinical features the disease Bhagandara can be correlated with fistula in ano. Presently Ksharasutra therapy is found most approaching and attractive treatment modality among para-surgical procedures for fistula in ano. Guggulu Apamarga Ksharasutra which is widely used, having good binding nature and anti-inflammatory effect, But the main complaints reported by the patients are pain and discomfort during and after Ksharasutra procedure. So, instead of Guggulu, Sarjarasa was taken which is having binding property, Vedanasthapaka, Vrana Ropana and Vrana Shodhana Guna, for the Ksharasutra preparation.[2] A total of 30 subjects were taken, Trial group treated with Sarjarasa Apamarga Ksharasutra and control group treated with Guggulu Apamarga Ksharasutra. The study shows Sarjarasa Apamarga Ksharasutra had high efficacy in subjective parameters like pain and burning sensation compared to Guggulu Apamarga Ksharasutra. There were no complications like necrosis, stenosis, anal incontinence after application of Sarjarasa Apamarga Ksharasutra.

show abstract

Proficiency of Khanduchakka Ghrit in the management of Parikartika: A case report

Cited by 4 publications

References 2 publications

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis

Mechanistic Insights and Therapeutic Potential of Natural Products in Amelioration of Wound Healing

A randomized, controlled clinical study to evaluate the role of Sarjarasa Apamarga Ksharasutra in the management of Bhagandara w.s.r to fistula-in-ano

Contact Info

Product

Resources

About