Profenofos metabolites in human poisoning

Gotoh, Miyuki; Sakata, Masakatsu; Endo, Tokiko; Hayashi, Hideyuki; Seno, Hiroshi; Сузукі, Осаму

doi:10.1016/s0379-0738(00)00377-7

Cited by 36 publications

(36 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The organophosphorus, profenofos [(O-4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate] is a broad-spectrum organophosphate insecticide and acaricide used widely for agricultural and household purposes (Prabhavathy et al, 2006). The toxicity by profenofos appeared fatal even at a relatively low plasma concentration as recorded in a case of fatal human poisoning where high concentrations of metabolites were detected suggests profenofos is rapidly metabolized (Gotoh et al, 2001). Profenofos is bioactivated, probably by phosphorothioate oxidation with microsomal enzyme and NADPH (Wing et al, 1983;Glickman et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Testicular toxicity of profenofos in matured male rats

et al. 2007

View full text Add to dashboard Cite

To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real time RT-PCR which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined which revealed testicular destruction and degeneration represented by a layer of columner epithelium, oedematous changes surrounding the siminiferous tubules besides vacuolated spermatogonial calls and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above 3 steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Testicular toxicity of profenofos in matured male rats

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Profenofos is reported to be highly toxic to human, animals and aquatic organisms (13)(14)(15) . Its main physiological effect is the inhibition of cholinesterase (ChE) activity (16) .…”

Section: Profenofos O-[4-bromo-2-chlorophenyl] O-ethyl S-propyl Phosmentioning

confidence: 99%

“…The objectives of the present study are (1) determination and identification of profenofos residues in soybean seeds and oils, (2) deducing the effect ofrefining processes on the level and nature of 14 C-labelled profenofos residues in crude soybean oil, (3) investigation the bioavailability of its bound residues in rats and (4) studying the effect of subchronic exposure to profenofos residues as well as the protective action of cinnamon on rats.…”

Section: Profenofos O-[4-bromo-2-chlorophenyl] O-ethyl S-propyl Phosmentioning

confidence: 99%

“…Stirring was continued for 4 hr, followed by dropwise addition of 14 C-ethyl alcohol (0.0048 mole, 3ml, 37 MBq) in dry benzene . The reaction mixture was stirred at 25ºC for 18 hr and filter.…”

Section: Synthesis Of 14 C-ethoxy Profenofos (I)mentioning

confidence: 99%

“…C-ethoxy profenofos (I) has been prepared according to Hegazi et al (22) in one vesseled reaction by condensation of equimolar amounts of 4-bromo-2-chlorophenol with S-propyl phosphorodichloridothioate followed by dropwise addition of 14 C-ethanol as follows:…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

2011

Egypt. J. Chem.

View full text Add to dashboard Cite

Luciferin Synthesis and Pesticide Detection by Luminescence Enzymatic Cascades

et al. 2022

View full text Add to dashboard Cite

D-Luciferin (D-LH 2 ), a substrate of firefly luciferase (Fluc), is important for a wide range of bioluminescence applications. This work reports a new and green method using enzymatic reactions (HELP, HadA Enzyme for Luciferin Preparation) to convert 19 phenolic derivatives to 8 D-LH 2 analogues with � 51 % yield. The method can synthesize the novel 5'-methyl-D-LH 2 and 4',5'-dimethyl-D-LH 2 , which have never been synthesized or found in nature. 5'-Methyl-D-LH 2 emits brighter and longer wavelength light than the D-LH 2 . Using HELP, we further developed LUMOS (Luminescence Measurement of Organophosphate and Derivatives) technology for in situ detection of organophosphate pesticides (OPs) including parathion, methyl parathion, EPN, profenofos, and fenitrothion by coupling the reactions of OPs hydrolase and Fluc. The LUMOS technology can detect these OPs at parts per trillion (ppt) levels. The method can directly detect OPs in food and biological samples without requiring sample pretreatment.

show abstract

Profenofos metabolites in human poisoning

Cited by 36 publications

References 9 publications

Testicular toxicity of profenofos in matured male rats

Testicular toxicity of profenofos in matured male rats

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

Luciferin Synthesis and Pesticide Detection by Luminescence Enzymatic Cascades

Contact Info

Product

Resources

About