PROF-ETEV study: prophylaxis of venous thromboembolic disease in critical care units in Spain

García-Olivares, Pablo; Guerrero, José Eugenio; Galdos, Pedro; Carriedo, Demetrio; Murillo, Francisco Martinez; Rivera, A.M. Castillo

doi:10.1007/s00134-014-3442-1

Cited by 22 publications

(8 citation statements)

References 35 publications

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“…Patients who developed VTE had significantly longer ICU and hospital stays, at 17 (IQR [11][12][13][14][15][16][17][18][19][20][21][22] and 33 (IQR 20-56) days compared to 12 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and 23 (13-40) days, respectively (p < 0.001 for both). Median time on mechanical ventilation was longer in patients who developed VTE compared to those who did not, 11 days (IQR 6-17) compared to [8][9][10][11][12][13][14], p < 0.001.…”

Section: Occurrence Of Vte and Outcomementioning

confidence: 99%

“…The reasons for the higher incidence of VTE in TBI patients are likely multifactorial and may include fractures of the pelvis and lower extremity and, perhaps, delays in initiation of PP. Indeed, studies have shown the use of inappropriate pharmacologic prophylaxis in up to 70% patients with major trauma [19].…”

Section: Relationship With Previous Studiesmentioning

confidence: 99%

“…The age-related effect has been attributed to increases in various coagulation factors [21], increased tendency to platelet aggregation [22], impaired fibrinolysis [23] and pathophysiologic changes in the vasculature [24]. Previous studies have also linked obesity with the development of VTE [19]. This may be related to venous stasis [25] and a pro-thrombotic state [26].…”

Section: Relationship With Previous Studiesmentioning

confidence: 99%

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Venous thromboembolic events in critically ill traumatic brain injury patients

et al. 2016

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Section: Occurrence Of Vte and Outcomementioning

confidence: 99%

Section: Relationship With Previous Studiesmentioning

confidence: 99%

Section: Relationship With Previous Studiesmentioning

confidence: 99%

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Venous thromboembolic events in critically ill traumatic brain injury patients

et al. 2016

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“…No VTE prophylaxis was given to 19% of the patients. 45 In a large observational study of 294,896 hospital discharges from adult ICUs in the United States, 93% of patients admitted to medical-surgical ICUs received VTE prophylaxis (27% anticoagulant only, 34% mechanical only, and 32% both). 10 In summary, almost all recent studies have demonstrated that more than 80% of critically ill patients receive appropriate VTE prophylaxis (►Table 2).…”

Section: Thromboprophylaxis Compliance and "Real-world Use" Of Vte Prmentioning

confidence: 99%

Venous Thromboembolism Prophylaxis in Critically Ill Patients

Boonyawat

Crowther

2015

Semin Thromb Hemost

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Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is recognized as a common complication in critically ill patients. Risk factors including critical illness, mechanical ventilation, sedative medications, and central venous catheter insertion are major contributing factors to the high risk of VTE. Because of their impaired cardiopulmonary reserve, PE arising from thrombosis in the deep veins of the calf that propagates proximally is poorly tolerated by critically ill patients. Pharmacologic prophylaxis with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) has been shown to decrease the incidence of VTE in medical, surgical, and critically ill patients. As a result, over the past decades, VTE prophylaxis had become a standard of preventive measure in the intensive care unit (ICU). In clinical practice, the rate of VTE prophylaxis varies and may be inadequate in some centers. A perception of a high bleeding risk in critically ill patients is a major concern for most physicians that may lead to inadequate prophylaxis.

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“…Graduated compression stockings, however, appear to have no role in preventing DVT [ 32 ]. These data suggest that in high to very high risk patients a combination of pharmacologic prophylaxis (if not contraindicated) together with SCD's are indicated [ 19 ]. As is evidenced from Table 27.2 trauma patients are at a very high risk of DVT.…”

Section: The Veins Of the Lower Limbmentioning

confidence: 89%

Venous Thromboembolic Disease: DVT and PE

Marik

2014

Evidence-Based Critical Care

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Deep venous thrombosis (DVT) and pulmonary emboli (PE) are usually considered the same disease, namely, thromboembolic disease (TED), as a large proportion of patients with DVT have "asymptomatic" PE and about 40 % of patients with PE have "asymptomatic DVT". Furthermore, in most instances the treatment is the same. TED is a common disorder that carries a high mortality rate. In a population based study performed in Canada, Tagalakis and colleagues reported an incidence of venous thromboembolism of 0.90 per 1,000 person-years; the 30-day and 1-year case-fatality rates were 10.6 % and 23.0 % respectively [ 1 ]. The 1-year survival rate was 47 % in patients with cancer, 93 % in patients with unprovoked venous thromboembolism and 84 % in patients with venous thromboembolism secondary to a major risk factor. In this study 62 % of cases were associated with a major risk factor, with cancer, hospitalization, and surgery being the most common. In the International Cooperative Pulmonary Embolism Registry (ICOPER), all-cause mor ta lity rate at 3 month was 17 % [ 2 ]. PE was considered to be the cause of death in 45 % of patients. Important prognostic factors associated with death from pulmonary embolism were age older than 70 years, cancer, congestive heart failure, chronic obstructive pulmonary disease, systolic arterial hypotension, tachypnea, and right ventricular hypokinesis on echocardiography.

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PROF-ETEV study: prophylaxis of venous thromboembolic disease in critical care units in Spain

Abstract: Most critically ill patients are at high or very high risk of VTE, but there is a low rate of appropriate prophylaxis. The efforts to improve the identification of patients at risk, and the implementation of appropriate prevention protocols should be enhanced.

Cited by 22 publications

References 35 publications

Venous thromboembolic events in critically ill traumatic brain injury patients

Venous thromboembolic events in critically ill traumatic brain injury patients

Venous Thromboembolism Prophylaxis in Critically Ill Patients

Venous Thromboembolic Disease: DVT and PE

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