Produtos naturais utilizados para tratamento de asma em crianças residentes na cidade de Salvador-BA, Brasil

Costa, Ryan dos Santos; Brasil, Tamires C.; Santos, Carla de Jesus; Santos, Djanilson Barbosa dos; Barreto, Mauricio López; Neves, Neuza Maria Alcântara; Figueiredo, Camila A.

doi:10.1590/s0102-695x2010000400020

Cited by 16 publications

(12 citation statements)

References 26 publications

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“…Based on the lack of an effective drug for asthma treatment without significant side effects, an ethnopharmacological survey was conducted by our research group in the city of Salvador, Bahia, Brazil, in order to find out the main natural products administered for the treatment of asthma in children, aiming at identifying plant species that could be the object of future studies as source of anti-asthmatic drugs [8].…”

Section: Introductionmentioning

confidence: 99%

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Costa

Carneiro

Cerqueira-Lima

et al. 2012

International Immunopharmacology

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Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) is a plant widely used in Brazilian folk medicine to treat inflammatory disorders, such as asthma. In the present study we evaluated the immunomodulatory effects of Og and rosmarinic acid (RA, a polyphenolic compound) in a murine model of respiratory allergy induced by the Blomia tropicalis (Bt) mite. The respiratory allergy was induced in A/J mice by administration of Bt extract and the treatment was done using 25, 50 or 100mg/kg of an Og methanolic extract or using 2, 20 or 200mg/kg of RA. We then evaluated the changes induced by these drugs on immunological parameters related to the allergic process, which are up-regulated in this allergic model. The treatment of animals with 100mg/Kg Og and 200mg/Kg RA led to a significant reduction in the numbers of leukocytes/eosinophils in bronchoalveolar lavage (BAL); eosinophil peroxidase activity in BAL; presence of mucus in respiratory tract, histopathological changes in the lung, and IL-4 in BAL. These results suggest that the methanolic extract of Og and the polyphenol RA have therapeutic potential in this murine model of respiratory allergy to a clinically relevant human sensitizer allergen.

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Section: Introductionmentioning

confidence: 99%

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Costa

Carneiro

Cerqueira-Lima

et al. 2012

International Immunopharmacology

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“…More recently, a study performed by Costa and colleagues [49] described the main natural sources for the treatment of asthma used by the Brazilian families from the Northeast Region of the country [49]. e study included beet, honey, onion, lemon, garlic, yarrow, and mint, demonstrating the wide variety of natural products used on asthma treatment in children [49]. Additionally, other natural-derived products have been widely cited in asthma treatment, such as natural oils from plants and animals, which can be obtained by different extraction process [52,53].…”

Section: Natural Products As Alternative Formentioning

confidence: 98%

“…Moreover, the use of natural products as complementary therapy represents an important alternative for the treatment of several diseases [49]. In the United States of America, the use of natural products, vitamins, and other dietary supplements as auxiliary treatments represent about 40% of the conventional therapies [50].…”

Section: Natural Products As Alternative Formentioning

confidence: 99%

“…e use of plant-based products for asthma treatment has been reported by the traditional medicine for over 5000 years, since the use by the Chinese culture of the infusion of Ephedra sinica, which is as an immune system stimulator able to decrease asthma crises [20]. More recently, a study performed by Costa and colleagues [49] described the main natural sources for the treatment of asthma used by the Brazilian families from the Northeast Region of the country [49]. e study included beet, honey, onion, lemon, garlic, yarrow, and mint, demonstrating the wide variety of natural products used on asthma treatment in children [49].…”

Section: Natural Products As Alternative Formentioning

confidence: 99%

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Use of Natural Products in Asthma Treatment

Amaral-Machado

Oliveira

Moreira-Oliveira

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Asthma, a disease classified as a chronic inflammatory disorder induced by airway inflammation, is triggered by a genetic predisposition or antigen sensitization. Drugs currently used as therapies present disadvantages such as high cost and side effects, which compromise the treatment compliance. Alternatively, traditional medicine has reported the use of natural products as alternative or complementary treatment. The aim of this review was to summarize the knowledge reported in the literature about the use of natural products for asthma treatment. The search strategy included scientific studies published between January 2006 and December 2017, using the keywords “asthma,” “treatment,” and “natural products.” The inclusion criteria were as follows: (i) studies that aimed at elucidating the antiasthmatic activity of natural-based compounds or extracts using laboratory experiments (in vitro and/or in vivo); and (ii) studies that suggested the use of natural products in asthma treatment by elucidation of its chemical composition. Studies that (i) did not report experimental data and (ii) manuscripts in languages other than English were excluded. Based on the findings from the literature search, aspects related to asthma physiopathology, epidemiology, and conventional treatment were discussed. Then, several studies reporting the effectiveness of natural products in the asthma treatment were presented, highlighting plants as the main source. Moreover, natural products from animals and microorganisms were also discussed and their high potential in the antiasthmatic therapy was emphasized. This review highlighted the importance of natural products as an alternative and/or complementary treatment source for asthma treatment, since they present reduced side effects and comparable effectiveness as the drugs currently used on treatment protocols.

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“…The species (Poaceae-Gramineae), commonly known as lemongrass, is a spontaneous perennial grass that is largely distributed around the world, especially in tropical and subtropical countries [ 12 ]. Our group’s interest in investigating this plant was because it was often used as a treatment of asthma and other respiratory allergies by folk medicine in the city of Salvador, Bahia, Brazil [ 13 ]. Extracts of dried Cy leaves are used in traditional medicine for the treatment of inflammation, digestive disorders, diabetes, nervous disorders, and fever, as well as other health problems [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation

Machado

Silva

Rios

et al. 2015

BMC Complement Altern Med

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BackgroundThe prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma.MethodsWe used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model. A/J mice were sensitized (100 μg/animal s.c.) and challenged (10 μg/animal i.n.) with Bt mite extract and treated with 60, 120 or 180 mg/kg of Cy standardized hexane extract. The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; Th2 cytokine concentrations in BAL and expression of NF-κB.ResultsOur results showed that oral administration of a Cy hexane extract (especially 180 mg/Kg) reduced the numbers of leukocytes/eosinophils in BAL; the eosinophil peroxidase activity in BAL; the infiltration of leukocytes in lung tissue; the production of mucus in the respiratory tract; the level of IL-4 in BAL and the nuclear expression of NF-κB.ConclusionsThe results presented demonstrate the potential of the Cy hexane extract to modulate allergic asthma; this extract may be an alternative future approach to treat this pathology.

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Produtos naturais utilizados para tratamento de asma em crianças residentes na cidade de Salvador-BA, Brasil

Cited by 16 publications

References 26 publications

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Use of Natural Products in Asthma Treatment

The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation

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